tert-Butyl 4-[2-[3-fluoro-4-((R)-2-hydroxy-1-methylethylcarbamoyl)phenoxymethyl]pyridin-5-yl]piperidine-1-carboxylate

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Chemical Name:tert-Butyl 4-[2-[3-fluoro-4-((R)-2-hydroxy-1-methylethylcarbamoyl)phenoxymethyl]pyridin-5-yl]piperidine-1-carboxylate
CAS No.:1206967-84-1
Molecular Formula:C₂₆H₃₄FN₃O₅
Molecular Weight:487.571
Hs Code.:

Synonyms:tert-Butyl 4-[2-[3-fluoro-4-((R)-2-hydroxy-1-methylethylcarbamoyl)phenoxymethyl]pyridin-5-yl]piperidine-1-carboxylate

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Chemical Property of tert-Butyl 4-[2-[3-fluoro-4-((R)-2-hydroxy-1-methylethylcarbamoyl)phenoxymethyl]pyridin-5-yl]piperidine-1-carboxylate

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Technology Process of tert-Butyl 4-[2-[3-fluoro-4-((R)-2-hydroxy-1-methylethylcarbamoyl)phenoxymethyl]pyridin-5-yl]piperidine-1-carboxylate

There total 6 articles about tert-Butyl 4-[2-[3-fluoro-4-((R)-2-hydroxy-1-methylethylcarbamoyl)phenoxymethyl]pyridin-5-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2749-11-3
(S)-Alaninol

: 1206967-79-4
tert-butyl 4-[2-(4-carboxy-3-fluorophenoxymethyl)pyridin-5-yl]piperidine-1-carboxylate

: 1206967-84-1
tert-Butyl 4-[2-[3-fluoro-4-((R)-2-hydroxy-1-methylethylcarbamoyl)phenoxymethyl]pyridin-5-yl]piperidine-1-carboxylate

Guidance literature:: tert-butyl 4-[2-(4-carboxy-3-fluorophenoxymethyl)pyridin-5-yl]piperidine-1-carboxylate; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 1h;

(S)-Alaninol; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 88139-91-7
(5-bromopyridin-2-yl)methanol

: 1206967-84-1
tert-Butyl 4-[2-[3-fluoro-4-((R)-2-hydroxy-1-methylethylcarbamoyl)phenoxymethyl]pyridin-5-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; tetrahydrofuran / 2.5 h / 90 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3.1: triethylamine / water; tetrahydrofuran / 0.17 h / 20 °C

4.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

5.1: water; lithium hydroxide monohydrate / ethanol / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 1 h / 20 °C

6.2: 20 °C

With lithium hydroxide monohydrate; water; hydrogen; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 286961-15-7
benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1 (2H)-pyridinecarboxylate

: 1206967-84-1
tert-Butyl 4-[2-[3-fluoro-4-((R)-2-hydroxy-1-methylethylcarbamoyl)phenoxymethyl]pyridin-5-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; tetrahydrofuran / 2.5 h / 90 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3.1: triethylamine / water; tetrahydrofuran / 0.17 h / 20 °C

4.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

5.1: water; lithium hydroxide monohydrate / ethanol / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 1 h / 20 °C

6.2: 20 °C

With lithium hydroxide monohydrate; water; hydrogen; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;