(R)-2-((tert-Butoxycarbonyl)amino)-2-methyl-3-phenylpropanoic acid

Base Information Edit

Chemical Name:(R)-2-((tert-Butoxycarbonyl)amino)-2-methyl-3-phenylpropanoic acid
CAS No.:111771-58-5
Molecular Formula:C15H21 N O4
Molecular Weight:279.336
Hs Code.:29225090
DSSTox Substance ID:DTXSID601197242
Mol file:111771-58-5.mol

Synonyms:Boc-alpha-methyl-D-Phe;(R)-2-((tert-Butoxycarbonyl)amino)-2-methyl-3-phenylpropanoic acid;Boc-alpha-methyl-D-phenylalanine;111771-58-5;53940-88-8;Boc-alpha-benzyl-D-Ala;(2R)-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoic acid;(R)-2-(tert-butoxycarbonylamino)-2-methyl-3-phenylpropanoic acid;(R)-N-Boc-2-benzylalanine;Boc-D-(Me)Phe-OH;SCHEMBL1552723;FAXPKABRZLISKX-OAHLLOKOSA-N;DTXSID601197242;(2R)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-phenylpropanoic acid;MFCD02682673;AKOS015836497;AB88715;PS-12815;CS-0179039;Boc-|A inverted exclamation mark-benzyl-D-Ala;F86533;A897997;N-(tert-butoxycarbonyl)-alpha-methyl-D-phenylalanine;(R)-N-(tert-butoxycarbonyl)-alpha-methylphenylalanine;(R)-N-(tert-butyloxycarbonyl)-alpha-methylphenylalanine;N-[(1,1-Dimethylethoxy)carbonyl]-a-methyl-L-phenylalanine;N-[(1,1-Dimethylethoxy)carbonyl]-alpha-methyl-D-phenylalanine;(R)-2-((tert-Butoxycarbonyl)amino)-2-methyl-3-phenylpropanoicacid;(2R)-2-{[(tert-butoxy)carbonyl]amino}-2-methyl-3-phenylpropanoic acid

Suppliers and Price of (R)-2-((tert-Butoxycarbonyl)amino)-2-methyl-3-phenylpropanoic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Boc-α-Methyl-L-phenylalanine
100mg
$ 95.00

SynChem
Boc-alpha-methyl-L-phenylalanine 95%
1 g
$ 135.00

Matrix Scientific
Boc-alpha-methyl-L-phenylalanine
1g
$ 135.00

Matrix Scientific
Boc-alpha-methyl-L-phenylalanine
250mg
$ 58.00

Crysdot
(R)-2-((tert-Butoxycarbonyl)amino)-2-methyl-3-phenylpropanoicacid 95+%
25g
$ 485.00

ChemPep
Boc-α-Me-D-Phe-OH
5g
$ 675.00

ChemPep
Boc-α-Me-D-Phe-OH
1g
$ 225.00

Chem-Impex
Boc-α-methyl-L-phenylalanine ≥ 98% (HPLC)
5G
$ 580.00

Chem-Impex
Boc-α-methyl-L-phenylalanine ≥ 98% (HPLC)
1G
$ 125.00

Chem-Impex
Boc-α-methyl-L-phenylalanine,98%(HPLC) 98%(HPLC)
250MG
$ 67.20

Total 18 raw suppliers

Chemical Property of (R)-2-((tert-Butoxycarbonyl)amino)-2-methyl-3-phenylpropanoic acid Edit

Chemical Property:

Boiling Point:432.1±38.0 °C(Predicted)
PKA:3.92±0.11(Predicted)
PSA：75.63000
Density:1.140±0.06 g/cm3(Predicted)
LogP:2.98800
Storage Temp.:2-8°C
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:279.14705815
Heavy Atom Count:20
Complexity:355

Purity/Quality:

98%min ^*data from raw suppliers

Boc-α-Methyl-L-phenylalanine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(C)(CC1=CC=CC=C1)C(=O)O
Isomeric SMILES:C[C@@](CC1=CC=CC=C1)(C(=O)O)NC(=O)OC(C)(C)C
Uses Boc-α-methyl-L-phenylalanine was a useful reagent in discovery of oxadiazoyl tertiary carbinamine inhibitors of β-?secretase (BACE-?1)?. It was also used in the study for strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.

Technology Process of (R)-2-((tert-Butoxycarbonyl)amino)-2-methyl-3-phenylpropanoic acid

There total 27 articles about (R)-2-((tert-Butoxycarbonyl)amino)-2-methyl-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%