ethyl 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-1,6-naphthyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-1,6-naphthyridine-3-carboxylate
• CAS No.: 1586754-99-5
• Molecular Formula: C₂₆H₂₈N₄O₃
• Molecular Weight: 444.533

Synonyms:ethyl 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-1,6-naphthyridine-3-carboxylate

Chemical Property of ethyl 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-1,6-naphthyridine-3-carboxylate

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Technology Process of ethyl 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-1,6-naphthyridine-3-carboxylate

There total 5 articles about ethyl 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-1,6-naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-(1,1-dimethylethyl)-benzenamine (6310-21-0) + ethyl 4-chloro-7-(3,5-dimethylisoxazol-4-yl)-1,6-naphthyridine-3-carboxylate (1586755-23-8) → ethyl 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-1,6-naphthyridine-3-carboxylate (1586754-99-5)

Guidance literature:

for 0.0166667h; Sealed tube;

DOI:10.1002/cmdc.201300259

Reference yield:

2-bromo-4-aminopyridine (7598-35-8) → ethyl 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-1,6-naphthyridine-3-carboxylate (1586754-99-5)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate / 1,2-dimethoxyethane; water / 72 h / Reflux

2: 1 h / 120 °C

3: diphenylether / 2 h / 260 °C

4: trichlorophosphate / 48 h / 90 °C

5: 0.02 h / Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate; trichlorophosphate; In 1,2-dimethoxyethane; diphenylether; water; 1: |Suzuki Coupling;

DOI:10.1002/cmdc.201300259

Reference yield:

2-(3,5-dimethylisoxazol-4-yl)pyridin-4-amine (1586754-95-1) → ethyl 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-1,6-naphthyridine-3-carboxylate (1586754-99-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1 h / 120 °C

2: diphenylether / 2 h / 260 °C

3: trichlorophosphate / 48 h / 90 °C

4: 0.02 h / Sealed tube

With trichlorophosphate; In diphenylether;

DOI:10.1002/cmdc.201300259

upstream raw materials:

2-(3,5-dimethylisoxazol-4-yl)pyridin-4-amine

3,5-dimethylisoxazole-4-boronic acid

2-bromo-4-aminopyridine

diethyl 2-(((2-(3,5-dimethylisoxazol-4-yl)pyridin-4-yl)amino)methylene)malonate

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