ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-(3,7-dimethyl-6-octenoyl)-4-piperidinecarboxylate

Base Information

Chemical Name:ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-(3,7-dimethyl-6-octenoyl)-4-piperidinecarboxylate
CAS No.:152876-20-5
Molecular Formula:C₃₃H₄₃F₂NO₄
Molecular Weight:555.706
Hs Code.:

Synonyms:ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-(3,7-dimethyl-6-octenoyl)-4-piperidinecarboxylate

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Chemical Property of ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-(3,7-dimethyl-6-octenoyl)-4-piperidinecarboxylate

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Technology Process of ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-(3,7-dimethyl-6-octenoyl)-4-piperidinecarboxylate

There total 4 articles about ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-(3,7-dimethyl-6-octenoyl)-4-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 152876-18-1
ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-(3,7-dimethyl-1-hydroxy-6-octenyl)-4-piperidinecarboxylate

: 152876-20-5
ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-(3,7-dimethyl-6-octenoyl)-4-piperidinecarboxylate

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃; for 0.25h;
DOI:10.1248/cpb.41.882

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 152876-20-5
ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-(3,7-dimethyl-6-octenoyl)-4-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / Na₂CO₃, NaI / various solvent(s) / 17 h / Heating

2: 1.) N,N,N',N'-tetramethylethylenediamine, LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 15 min

3: 88 percent / oxalyl chloride, DMSO, Et₃N / CH₂Cl₂ / 0.25 h / -78 °C

With oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; sodium carbonate; dimethyl sulfoxide; triethylamine; sodium iodide; lithium diisopropyl amide; In dichloromethane;
DOI:10.1248/cpb.41.882

Reference yield:

: 50366-31-9
2-[bis(4-fluorophenyl)methoxy]ethyl chloride

: 152876-20-5
ethyl 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-(3,7-dimethyl-6-octenoyl)-4-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / Na₂CO₃, NaI / various solvent(s) / 17 h / Heating

2: 1.) N,N,N',N'-tetramethylethylenediamine, LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 15 min

3: 88 percent / oxalyl chloride, DMSO, Et₃N / CH₂Cl₂ / 0.25 h / -78 °C

With oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; sodium carbonate; dimethyl sulfoxide; triethylamine; sodium iodide; lithium diisopropyl amide; In dichloromethane;
DOI:10.1248/cpb.41.882