[1-(Toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-acetyl chloride

Base Information

• Chemical Name: [1-(Toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-acetyl chloride
• CAS No.: 134594-43-7
• Molecular Formula: C₁₉H₂₀ClNO₃S
• Molecular Weight: 377.892
• Mol file: 134594-43-7.mol

Synonyms:[1-(Toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-acetyl chloride

Chemical Property of [1-(Toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-acetyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(Toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-acetyl chloride

There total 1 articles about [1-(Toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(Toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-acetic acid (134594-42-6) → [1-(Toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-acetyl chloride (134594-43-7)

Guidance literature:

With thionyl chloride; In benzene; for 12h; Heating;

DOI:10.1021/ja00015a033

Reference yield:

[1-(Toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-acetyl chloride (134594-43-7) → 5-(2-carboxyethyl)-N-tosyl-2,3,4,5-tetrahydrobenzazepine (134594-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 2 h / 0 °C

2: Ag₂O, Na₂CO₃, Na₂S₂O₃, water / dioxane / 5 h / 90 °C

With water; sodium carbonate; sodium thiosulfate; silver(l) oxide; In 1,4-dioxane; diethyl ether;

DOI:10.1021/ja00015a033

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + [1-(Toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-acetyl chloride (134594-43-7) → 1-Diazo-3-[1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-propan-2-one

Guidance literature:

In diethyl ether; at 0 ℃; for 2h;

DOI:10.1021/ja00015a033

upstream raw materials:

[1-(Toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-acetic acid

Downstream raw materials:

5-(2-carboxyethyl)-N-tosyl-2,3,4,5-tetrahydrobenzazepine