{[(4aS,13aR)-8-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazin-10-yl]oxy}methyl methyl carbonate

Base Information

Chemical Name:{[(4aS,13aR)-8-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazin-10-yl]oxy}methyl methyl carbonate
CAS No.:1206784-52-2
Molecular Formula:C₂₄H₂₄F₂N₄O₇
Molecular Weight:518.474
Hs Code.:

{[(4aS,13aR)-8-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazin-10-yl]oxy}methyl methyl carbonate

Synonyms:{[(4aS,13aR)-8-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazin-10-yl]oxy}methyl methyl carbonate

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Chemical Property of {[(4aS,13aR)-8-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazin-10-yl]oxy}methyl methyl carbonate

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Technology Process of {[(4aS,13aR)-8-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazin-10-yl]oxy}methyl methyl carbonate

There total 15 articles about {[(4aS,13aR)-8-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazin-10-yl]oxy}methyl methyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69862-08-4
iodomethyl methyl carbonate

: (4aS,13aR)-N-[(2,4-difluorophenyl)methyl]-10-hydroxy-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazine-8-carboxamide sodium salt

: 1206784-52-2
{[(4aS,13aR)-8-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazin-10-yl]oxy}methyl methyl carbonate

Guidance literature:: With potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water;

Reference yield:

: 118-71-8
Maltol

: 1206784-52-2
{[(4aS,13aR)-8-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazin-10-yl]oxy}methyl methyl carbonate

Guidance literature:: Multi-step reaction with 14 steps

1.1: potassium carbonate / acetonitrile / 5 h / 80 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -60 °C

2.2: 1 h / -60 °C

2.3: 2 °C

3.1: triethylamine / tetrahydrofuran / 30 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 0.5 h / 30 °C

5.1: sodium periodate / rhodium(III) chloride hydrate / water; ethyl acetate; acetonitrile / 1 h / 25 °C

5.2: 1 h / 25 °C

6.1: ethanol / 8.5 h / 65 - 80 °C

7.1: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one; water / 4 h / 20 °C

8.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 16.33 h / 18 - 20 °C

9.1: sodium periodate; water / 16 h / 1.4 - 20 °C

10.1: acetic acid / N,N-dimethyl-formamide; acetonitrile / 0.25 h

10.2: 6.33 h / 20 - 85 °C

11.1: N-ethyl-N,N-diisopropylamine / 1,1'-bis-(diphenylphosphino)ferrocene; palladium(II) trifluoroacetate / dimethyl sulfoxide / 24 h / 80 °C / 2327.23 Torr / Inert atmosphere

12.1: ammonium hydroxide; hydrogen / palladium on activated charcoal / ethanol; water / 2585.81 Torr

13.1: sodium hydroxide / ethanol; water / 14.33 h

14.1: potassium carbonate / tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water

With ammonium hydroxide; sodium periodate; N-Bromosuccinimide; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; 1,1'-bis-(diphenylphosphino)ferrocene; palladium(II) trifluoroacetate; rhodium(III) chloride hydrate; palladium on activated charcoal; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: (4aS,13aR)-N-[(2,4-difluorophenyl)methyl]-10-hydroxy-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazine-8-carboxamide

: 1206784-52-2
{[(4aS,13aR)-8-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazin-10-yl]oxy}methyl methyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 14.33 h

2: potassium carbonate / tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water

With potassium carbonate; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In ethanol; dichloromethane; water;