C₁₈H₁₂ClF₂N₃O₂

Base Information

Chemical Name:C₁₈H₁₂ClF₂N₃O₂
CAS No.:1190735-61-5
Molecular Formula:C₁₈H₁₂ClF₂N₃O₂
Molecular Weight:375.762
Hs Code.:

C<sub>18</sub>H<sub>12</sub>ClF<sub>2</sub>N<sub>3</sub>O<sub>2</sub>

Synonyms:C₁₈H₁₂ClF₂N₃O₂

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Chemical Property of C₁₈H₁₂ClF₂N₃O₂

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Technology Process of C₁₈H₁₂ClF₂N₃O₂

There total 7 articles about C₁₈H₁₂ClF₂N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1190735-60-4
C₁₈H₁₁ClF₂N₂O₃

: 1190735-61-5
C₁₈H₁₂ClF₂N₃O₂

Guidance literature:: C₁₈H₁₁ClF₂N₂O₃; With oxalyl dichloride; N,N-dimethyl-formamide; In chloroform; at 20 ℃; for 1h;

With ammonium hydroxide; In ethyl acetate; at 20 ℃; for 1h;

Reference yield:

: 110888-15-8
4-chloro-3-fluorobenzonitrile

: 1190735-61-5
C₁₈H₁₂ClF₂N₃O₂

Guidance literature:: Multi-step reaction with 7 steps

1.1: trimethylaluminum; ammonium chloride / toluene / 80 °C / Inert atmosphere

2.1: sodium ethanolate / ethanol / 3 h / Reflux

3.1: trichlorophosphate / N,N-dimethyl-aniline / 22 h / Reflux

4.1: sodium hydride / tetrahydrofuran / -78 - 20 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 2 h / Reflux; Inert atmosphere

6.1: water; sodium hydroxide / ethanol / 20 °C

7.1: oxalyl dichloride; N,N-dimethyl-formamide / chloroform / 1 h / 20 °C

7.2: 1 h / 20 °C

With oxalyl dichloride; water; trimethylaluminum; sodium ethanolate; sodium hydride; sodium carbonate; ammonium chloride; N,N-dimethyl-formamide; sodium hydroxide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; chloroform; water; N,N-dimethyl-aniline; toluene;

Reference yield:

: 1190735-16-0
4-chloro-3-fluorobenzamidine hydrochloride

: 1190735-61-5
C₁₈H₁₂ClF₂N₃O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium ethanolate / ethanol / 3 h / Reflux

2.1: trichlorophosphate / N,N-dimethyl-aniline / 22 h / Reflux

3.1: sodium hydride / tetrahydrofuran / -78 - 20 °C

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 2 h / Reflux; Inert atmosphere

5.1: water; sodium hydroxide / ethanol / 20 °C

6.1: oxalyl dichloride; N,N-dimethyl-formamide / chloroform / 1 h / 20 °C

6.2: 1 h / 20 °C

With oxalyl dichloride; water; sodium ethanolate; sodium hydride; sodium carbonate; N,N-dimethyl-formamide; sodium hydroxide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; chloroform; water; N,N-dimethyl-aniline;