{2-[3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphinic acid

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Chemical Name:{2-[3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphinic acid
CAS No.:197021-53-7
Molecular Formula:C₂₇H₃₅N₂O₆PSi
Molecular Weight:542.644
Hs Code.:

{2-[3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphinic acid

Synonyms:{2-[3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphinic acid

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Chemical Property of {2-[3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphinic acid

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Technology Process of {2-[3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphinic acid

There total 5 articles about {2-[3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 197021-52-6
{2-[3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphinic acid ethyl ester

: 197021-53-7
{2-[3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphinic acid

Guidance literature:: With triethylamine; In ethanol; at 20 ℃;
DOI:10.1055/s-2001-12328

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 197021-53-7
{2-[3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / imidazole / dimethylformamide / 20 °C

2: 71 percent / Me₃SiCl; EtOH / CHCl₃ / 20 °C

3: 98 percent / Et₃N / aq. ethanol / 20 °C

With 1H-imidazole; chloro-trimethyl-silane; ethanol; triethylamine; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-12328

Reference yield:

: 197021-51-5
(1,1-Diethoxy-ethyl)-{2-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphinic acid ethyl ester

: 197021-53-7
{2-[3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / imidazole / dimethylformamide / 20 °C

2: 71 percent / Me₃SiCl; EtOH / CHCl₃ / 20 °C

3: 98 percent / Et₃N / aq. ethanol / 20 °C

With 1H-imidazole; chloro-trimethyl-silane; ethanol; triethylamine; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-12328