1-methyl-6-(4-(2-(4-(6-methylpyridin-2-yl)piperazin-1-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

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Chemical Name:1-methyl-6-(4-(2-(4-(6-methylpyridin-2-yl)piperazin-1-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile
CAS No.:1315464-19-7
Molecular Formula:C₂₆H₂₅F₃N₈O
Molecular Weight:522.533
Hs Code.:

Synonyms:1-methyl-6-(4-(2-(4-(6-methylpyridin-2-yl)piperazin-1-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

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Chemical Property of 1-methyl-6-(4-(2-(4-(6-methylpyridin-2-yl)piperazin-1-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

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Technology Process of 1-methyl-6-(4-(2-(4-(6-methylpyridin-2-yl)piperazin-1-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

There total 9 articles about 1-methyl-6-(4-(2-(4-(6-methylpyridin-2-yl)piperazin-1-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55745-89-6
1-(6-methylpyridin-2-yl)piperazine

: 1315465-20-3
2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl methanesulfonate

: 1315464-19-7
1-methyl-6-(4-(2-(4-(6-methylpyridin-2-yl)piperazin-1-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 0.5h; Microwaves;

Reference yield:

: 50824-04-9
4-bromo-2-(trifluoromethyl)phenol

: 1315464-19-7
1-methyl-6-(4-(2-(4-(6-methylpyridin-2-yl)piperazin-1-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetonitrile / Reflux

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

3: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

4: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / 1 h / 0 - 20 °C

6: 1-methyl-pyrrolidin-2-one / 0.5 h / 150 °C / Microwaves

With hydrogenchloride; potassium phosphate; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; acetonitrile;

Reference yield:

: 944388-71-0
4-amino-6-chloro-3-nitropyridine-2-carbonitrile

: 1315464-19-7
1-methyl-6-(4-(2-(4-(6-methylpyridin-2-yl)piperazin-1-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetonitrile / 5 h / 80 °C

2: tin(II) chloride dihdyrate / ethanol / 3 h / 20 °C

3: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

4: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / 1 h / 0 - 20 °C

6: 1-methyl-pyrrolidin-2-one / 0.5 h / 150 °C / Microwaves

With hydrogenchloride; potassium phosphate; tin(II) chloride dihdyrate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; water; acetonitrile;