(1S,6S)-2,2-dimethyl-6-hydroxy-1-[3'-(1''-phenyl-1''H-tetrazole-5''-sulfanyl)butyl]-cyclohexane

Base Information

Chemical Name:(1S,6S)-2,2-dimethyl-6-hydroxy-1-[3'-(1''-phenyl-1''H-tetrazole-5''-sulfanyl)butyl]-cyclohexane
CAS No.:924884-82-2
Molecular Formula:C₁₉H₂₈N₄OS
Molecular Weight:360.524
Hs Code.:

Synonyms:(1S,6S)-2,2-dimethyl-6-hydroxy-1-[3'-(1''-phenyl-1''H-tetrazole-5''-sulfanyl)butyl]-cyclohexane

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Chemical Property of (1S,6S)-2,2-dimethyl-6-hydroxy-1-[3'-(1''-phenyl-1''H-tetrazole-5''-sulfanyl)butyl]-cyclohexane

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Technology Process of (1S,6S)-2,2-dimethyl-6-hydroxy-1-[3'-(1''-phenyl-1''H-tetrazole-5''-sulfanyl)butyl]-cyclohexane

There total 8 articles about (1S,6S)-2,2-dimethyl-6-hydroxy-1-[3'-(1''-phenyl-1''H-tetrazole-5''-sulfanyl)butyl]-cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 924884-81-1
(1S,6S)-(+)-2,2-dimethyl-1-[3'-(1''-phenyl-1''H-tetrazole-5''-sulfanyl)butyl]-6-methoxymethyloxycyclohexane

: 924884-82-2
(1S,6S)-2,2-dimethyl-6-hydroxy-1-[3'-(1''-phenyl-1''H-tetrazole-5''-sulfanyl)butyl]-cyclohexane

Guidance literature:: With hydrogenchloride; In methanol; at 60 ℃; for 1.5h;
DOI:10.1016/j.tetasy.2006.11.015

Reference yield:

: 6-hydroxy-2,2-dimethyl-cyclohexanecarboxylic acid methyl ester

: 924884-82-2
(1S,6S)-2,2-dimethyl-6-hydroxy-1-[3'-(1''-phenyl-1''H-tetrazole-5''-sulfanyl)butyl]-cyclohexane

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / N,N-diisopropylethylamine / dimethylformamide / 2.5 h / 80 °C

2: 97 percent / LiAlH₄ / diethyl ether / 1.5 h / 20 °C

3: 8.78 g / I₂; triphenylphosphine; imidazole / tetrahydrofuran / 7 h / 20 °C

4: 77 percent / NaOMe / methanol / 13 h / 60 - 90 °C

5: 95 percent / aq. NaOH / methanol / 7.5 h / 100 °C

6: 3.686 g / NaBH₄ / methanol / 2.5 h / -78 °C

7: 78 percent / diethyl azodicarboxylate; triphenylphosphine / toluene; tetrahydrofuran / 1 h / 20 °C

8: 4.065 g / aq. HCl / methanol / 1.5 h / 60 °C

With 1H-imidazole; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; iodine; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetasy.2006.11.015

Reference yield:

: 924884-76-4
(1R,6S)-(+)-2,2-dimethyl-1-hydroxymethyl-6-methoxymethyloxycyclohexane

: 924884-82-2
(1S,6S)-2,2-dimethyl-6-hydroxy-1-[3'-(1''-phenyl-1''H-tetrazole-5''-sulfanyl)butyl]-cyclohexane

Guidance literature:: Multi-step reaction with 6 steps

1: 8.78 g / I₂; triphenylphosphine; imidazole / tetrahydrofuran / 7 h / 20 °C

2: 77 percent / NaOMe / methanol / 13 h / 60 - 90 °C

3: 95 percent / aq. NaOH / methanol / 7.5 h / 100 °C

4: 3.686 g / NaBH₄ / methanol / 2.5 h / -78 °C

5: 78 percent / diethyl azodicarboxylate; triphenylphosphine / toluene; tetrahydrofuran / 1 h / 20 °C

6: 4.065 g / aq. HCl / methanol / 1.5 h / 60 °C

With 1H-imidazole; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; iodine; sodium methylate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/j.tetasy.2006.11.015