methyl (2S)-1-[4-(6-fluoro-1,3-benzothiazol-2-yl)benzoyl]tetrahydro-1H-2-pyrrolecarboxylate

Base Information

Chemical Name:methyl (2S)-1-[4-(6-fluoro-1,3-benzothiazol-2-yl)benzoyl]tetrahydro-1H-2-pyrrolecarboxylate
CAS No.:1370531-57-9
Molecular Formula:C₂₀H₁₇FN₂O₃S
Molecular Weight:384.431
Hs Code.:

Synonyms:methyl (2S)-1-[4-(6-fluoro-1,3-benzothiazol-2-yl)benzoyl]tetrahydro-1H-2-pyrrolecarboxylate

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Chemical Property of methyl (2S)-1-[4-(6-fluoro-1,3-benzothiazol-2-yl)benzoyl]tetrahydro-1H-2-pyrrolecarboxylate

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Technology Process of methyl (2S)-1-[4-(6-fluoro-1,3-benzothiazol-2-yl)benzoyl]tetrahydro-1H-2-pyrrolecarboxylate

There total 7 articles about methyl (2S)-1-[4-(6-fluoro-1,3-benzothiazol-2-yl)benzoyl]tetrahydro-1H-2-pyrrolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239751-54-2
C₁₄H₇ClFNOS

: 2133-40-6
L-proline methyl ester monohydrochloride

: 1370531-57-9
methyl (2S)-1-[4-(6-fluoro-1,3-benzothiazol-2-yl)benzoyl]tetrahydro-1H-2-pyrrolecarboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.ejmech.2012.01.014

Reference yield:

: 1239752-25-0
4-(6-fluoro-1,3-benzothiazol-2-yl)benzoic acid

: 1370531-57-9
methyl (2S)-1-[4-(6-fluoro-1,3-benzothiazol-2-yl)benzoyl]tetrahydro-1H-2-pyrrolecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / benzene / Reflux

2: triethylamine / tetrahydrofuran / 20 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; benzene;
DOI:10.1016/j.ejmech.2012.01.014

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 1370531-57-9
methyl (2S)-1-[4-(6-fluoro-1,3-benzothiazol-2-yl)benzoyl]tetrahydro-1H-2-pyrrolecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C

2: Lawessons reagent / toluene / 2 h / Reflux

3: Dess-Martin periodane / dichloromethane / 0.25 h / 20 °C

4: chromium(VI) oxide; periodic acid / acetonitrile / 20 °C

5: thionyl chloride; N,N-dimethyl-formamide / benzene / Reflux

6: triethylamine / tetrahydrofuran / 20 °C

With Lawessons reagent; chromium(VI) oxide; thionyl chloride; Dess-Martin periodane; periodic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene; acetonitrile; benzene;
DOI:10.1016/j.ejmech.2012.01.014