1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
• CAS No.: 183269-46-7
• Molecular Formula: C₂₅H₃₀N₂O₅Si
• Molecular Weight: 466.609

Synonyms:1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Chemical Property of 1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Technology Process of 1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

There total 1 articles about 1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2'-deoxyuridine (951-78-0,63844-76-8) + tert-butylchlorodiphenylsilane (58479-61-1) → 1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione (183269-46-7)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at -50 - 20 ℃; for 4h;

DOI:10.3390/molecules23061457

Reference yield: 87.0%

1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione (183269-46-7) → 5'-O-(tert-butyldiphenylsilyl)-3'-keto-2'-deoxyuridine

Guidance literature:

With Dess-Martin periodane; In chloroform; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.3390/molecules23061457

Reference yield: 31.0%

ortho-iodophenyl chlorothionoformate + 1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione (183269-46-7) → C32H33IN2O7SSi

Guidance literature:

With dmap; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/anie.201910051

upstream raw materials:

2'-deoxyuridine

tert-butylchlorodiphenylsilane

Downstream raw materials:

2-diazo-3-oxo-butyric acid 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

2-diazo-malonic acid 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

1-[4-allyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

N-{1-[4-allyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-acetamide

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