(2S)-2-amino-N-{(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidinyl}butanamide hydrochloride

Base Information

Chemical Name:(2S)-2-amino-N-{(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidinyl}butanamide hydrochloride
CAS No.:1269408-34-5
Molecular Formula:C₁₆H₁₉F₃N₄O*ClH
Molecular Weight:376.809
Hs Code.:

Synonyms:(2S)-2-amino-N-{(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidinyl}butanamide hydrochloride

Suppliers and Price of (2S)-2-amino-N-{(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidinyl}butanamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-2-amino-N-{(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidinyl}butanamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-2-amino-N-{(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidinyl}butanamide hydrochloride

There total 4 articles about (2S)-2-amino-N-{(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidinyl}butanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1269407-05-7
1,1-dimethylethyl {(1S)-1-[({(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidinyl}amino)carbonyl]propyl}carbamate

: 1269408-34-5
(2S)-2-amino-N-{(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidinyl}butanamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1.5h;

Reference yield:

: 1269407-02-4
1,1-dimethylethyl {(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidinyl}carbamate

: 1269408-34-5
(2S)-2-amino-N-{(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidinyl}butanamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: triethylamine; HATU / dichloromethane; methanol / 0.25 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

With hydrogenchloride; triethylamine; HATU; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 1269407-03-5
2-[(3S)-3-amino-1-pyrrolidinyl]-5-(trifluoromethyl)benzonitrile hydrochloride

: 1269408-34-5
(2S)-2-amino-N-{(3S)-1-[2-cyano-4-(trifluoromethyl)phenyl]-3-pyrrolidinyl}butanamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; HATU / dichloromethane; methanol / 0.25 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

With hydrogenchloride; triethylamine; HATU; In 1,4-dioxane; methanol; dichloromethane;