N-(1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl)-2-hydroxy-4-methoxy-N-methylbenzamide

Base Information

Chemical Name:N-(1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl)-2-hydroxy-4-methoxy-N-methylbenzamide
CAS No.:1394017-82-3
Molecular Formula:C₂₀H₂₂ClNO₄
Molecular Weight:375.852
Hs Code.:

Synonyms:N-(1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl)-2-hydroxy-4-methoxy-N-methylbenzamide

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Chemical Property of N-(1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl)-2-hydroxy-4-methoxy-N-methylbenzamide

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Technology Process of N-(1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl)-2-hydroxy-4-methoxy-N-methylbenzamide

There total 3 articles about N-(1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl)-2-hydroxy-4-methoxy-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.7%

: 2237-36-7
4-methoxysalicylic acid

: 1368565-38-1
1-(4-chlorophenyl)-3-methyl-2-(methylamino)butan-1-one

: 1394017-82-3
N-(1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl)-2-hydroxy-4-methoxy-N-methylbenzamide

Guidance literature:: 4-methoxysalicylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

1-(4-chlorophenyl)-3-methyl-2-(methylamino)butan-1-one; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.07.032

Reference yield:

: 1394018-17-7
1-(4-chlorophenyl)-3-methyl-2-(methylamino)butan-1-ol

: 1394017-82-3
N-(1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl)-2-hydroxy-4-methoxy-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dess-Martin periodane / dichloromethane / 7 h / Inert atmosphere

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 20 °C

2.2: 20 °C / Inert atmosphere

With Dess-Martin periodane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.07.032

Reference yield:

: 1394017-59-4
tert-butyl 1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-ylcarbamate

: 1394017-82-3
N-(1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl)-2-hydroxy-4-methoxy-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 55 - 65 °C / Inert atmosphere

2.1: Dess-Martin periodane / dichloromethane / 7 h / Inert atmosphere

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; Dess-Martin periodane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.07.032