(Z)-2-(p-Bromobenzoyl)-1-<(3,4-dimethoxyphenyl)methylene>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(Z)-2-(p-Bromobenzoyl)-1-<(3,4-dimethoxyphenyl)methylene>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:104621-39-8
Molecular Formula:C₂₇H₂₆BrNO₅
Molecular Weight:524.411
Hs Code.:

Synonyms:(Z)-2-(p-Bromobenzoyl)-1-<(3,4-dimethoxyphenyl)methylene>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (Z)-2-(p-Bromobenzoyl)-1-<(3,4-dimethoxyphenyl)methylene>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (Z)-2-(p-Bromobenzoyl)-1-<(3,4-dimethoxyphenyl)methylene>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about (Z)-2-(p-Bromobenzoyl)-1-<(3,4-dimethoxyphenyl)methylene>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 6957-27-3
3,4-dihydropapaverine

: 586-75-4
4-chlorobenzoyl chloride

: (E)-2-(p-Bromobenzoyl)-1-<(3,4-dimethoxyphenyl)methylene>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 104621-39-8
(Z)-2-(p-Bromobenzoyl)-1-<(3,4-dimethoxyphenyl)methylene>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With triethylamine; In dichloromethane; at 23 ℃; for 0.5h; Yields of byproduct given;
DOI:10.1021/jo00081a007

Reference yield:

: 104621-39-8
(Z)-2-(p-Bromobenzoyl)-1-<(3,4-dimethoxyphenyl)methylene>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 154013-16-8
(S)-2-(p-Bromobenzoyl)-1-<(3,4-dimethoxyphenyl)methyl>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: (R)-2-(p-Bromobenzoyl)-1-<(3,4-dimethoxyphenyl)methyl>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With hydrogen; (S)-Ru(OAc)₂-BINAP; In methanol; dichloromethane; at 30 ℃; for 40h; under 3040 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00081a007

Reference yield:

: 104621-39-8
(Z)-2-(p-Bromobenzoyl)-1-<(3,4-dimethoxyphenyl)methylene>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 4747-98-2
S-(-)-Norlaudanosine

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Ru(CH₃COO)2<(S)-BINAP> / methanol; CH₂Cl₂ / 40 h / 30 °C / 3040 Torr

2: 55 percent / KOH, 80percent aq. NH₂NH₂ / ethane-1,2-diol / 15 h / 170 °C

With potassium hydroxide; hydrogen; hydrazine hydrate; (S)-Ru(OAc)₂-BINAP; In methanol; dichloromethane; ethylene glycol;
DOI:10.1021/jo00081a007