N₂-((1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)-N₁-(1-cyanocyclopropyl)-3-(2,3-difluorobenzylsulfonyl)-L-alaninamide

Base Information

• Chemical Name: N₂-((1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)-N₁-(1-cyanocyclopropyl)-3-(2,3-difluorobenzylsulfonyl)-L-alaninamide
• CAS No.: 1259967-37-7
• Molecular Formula: C₂₂H₁₉BrF₅N₃O₃S
• Molecular Weight: 580.373

Synonyms:N₂-((1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)-N₁-(1-cyanocyclopropyl)-3-(2,3-difluorobenzylsulfonyl)-L-alaninamide

Chemical Property of N₂-((1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)-N₁-(1-cyanocyclopropyl)-3-(2,3-difluorobenzylsulfonyl)-L-alaninamide

Chemical Property:

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Technology Process of N₂-((1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)-N₁-(1-cyanocyclopropyl)-3-(2,3-difluorobenzylsulfonyl)-L-alaninamide

There total 1 articles about N₂-((1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)-N₁-(1-cyanocyclopropyl)-3-(2,3-difluorobenzylsulfonyl)-L-alaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N2-((1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)-N1-(1-cyanocyclopropyl)-S-(2,3-difluorobenzyl)-L-cysteinamide (1259967-15-1) → N2-((1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)-N1-(1-cyanocyclopropyl)-3-(2,3-difluorobenzylsulfonyl)-L-alaninamide (1259967-37-7)

Guidance literature:

With dihydrogen peroxide; tetra(n-butyl)ammonium hydrogensulfate; ortho-tungstic acid; In water; ethyl acetate; at 0 - 20 ℃;

upstream raw materials:

N₂-((1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)-N₁-(1-cyanocyclopropyl)-S-(2,3-difluorobenzyl)-L-cysteinamide

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