1-(4-difluoromethoxy-phenylmethyl)-1H-indole-6-carboxylic acid hydroxyamide

Base Information

Chemical Name:1-(4-difluoromethoxy-phenylmethyl)-1H-indole-6-carboxylic acid hydroxyamide
CAS No.:950762-94-4
Molecular Formula:C₁₇H₁₄F₂N₂O₃
Molecular Weight:332.307
Hs Code.:

Synonyms:1-(4-difluoromethoxy-phenylmethyl)-1H-indole-6-carboxylic acid hydroxyamide

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Chemical Property of 1-(4-difluoromethoxy-phenylmethyl)-1H-indole-6-carboxylic acid hydroxyamide

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Technology Process of 1-(4-difluoromethoxy-phenylmethyl)-1H-indole-6-carboxylic acid hydroxyamide

There total 2 articles about 1-(4-difluoromethoxy-phenylmethyl)-1H-indole-6-carboxylic acid hydroxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 950763-28-7
1-(4-difluoromethoxy-phenylmethyl)-1H-indole-6-carboxylic acid methyl ester

: 950762-94-4
1-(4-difluoromethoxy-phenylmethyl)-1H-indole-6-carboxylic acid hydroxyamide

Guidance literature:: 1-(4-difluoromethoxy-phenylmethyl)-1H-indole-6-carboxylic acid methyl ester; With sodium hydroxide; hydroxylamine; In tetrahydrofuran; methanol; water; at 20 ℃; for 3h;

With hydrogenchloride; In water; pH=7 - 8;

Reference yield:

: 50820-65-0
indole-6-carboxylic acid methyl ester

: 3447-53-8
4-(difluoromethoxy)benzyl bromide

: 950762-94-4
1-(4-difluoromethoxy-phenylmethyl)-1H-indole-6-carboxylic acid hydroxyamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 3.5 h / 20 °C

2.1: sodium hydroxide; hydroxylamine / tetrahydrofuran; methanol; water / 3 h / 20 °C

2.2: pH 7 - 8

With sodium hydroxide; hydroxylamine; sodium hydride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;