4-methyl-N-[(S)-1-propyl-5-(tetrahydropyran-2-yloxy)pent-3-ynyl]benzenesulfonamide

Base Information

Chemical Name:4-methyl-N-[(S)-1-propyl-5-(tetrahydropyran-2-yloxy)pent-3-ynyl]benzenesulfonamide
CAS No.:329184-63-6
Molecular Formula:C₂₀H₂₉NO₄S
Molecular Weight:379.521
Hs Code.:

Synonyms:4-methyl-N-[(S)-1-propyl-5-(tetrahydropyran-2-yloxy)pent-3-ynyl]benzenesulfonamide

Suppliers and Price of 4-methyl-N-[(S)-1-propyl-5-(tetrahydropyran-2-yloxy)pent-3-ynyl]benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-methyl-N-[(S)-1-propyl-5-(tetrahydropyran-2-yloxy)pent-3-ynyl]benzenesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-methyl-N-[(S)-1-propyl-5-(tetrahydropyran-2-yloxy)pent-3-ynyl]benzenesulfonamide

There total 1 articles about 4-methyl-N-[(S)-1-propyl-5-(tetrahydropyran-2-yloxy)pent-3-ynyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 6089-04-9
3-(tetrahydropyran-2'-yloxy)propyne

: 170956-17-9
(S)-1-[(4-methylphenyl)sulfonyl]-2-propylaziridin

: 329184-63-6
4-methyl-N-[(S)-1-propyl-5-(tetrahydropyran-2-yloxy)pent-3-ynyl]benzenesulfonamide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 24h;
DOI:10.1021/jo001200w

Reference yield: 80.0%

: 139897-19-1
(2-bromoethoxy)(tert-butyl)diphenylsilane

: 329184-63-6
4-methyl-N-[(S)-1-propyl-5-(tetrahydropyran-2-yloxy)pent-3-ynyl]benzenesulfonamide

: 329184-64-7
N-[2-(tert-butyldiphenylsilanyloxy)ethyl]-4-methyl-N-[(S)-1-propyl-5-(tetrahydropyran-2-yloxy)pent-3-ynyl]benzenesulfonamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 40 ℃; for 48h;
DOI:10.1021/jo001200w

Reference yield:

: 329184-63-6
4-methyl-N-[(S)-1-propyl-5-(tetrahydropyran-2-yloxy)pent-3-ynyl]benzenesulfonamide

: 329184-80-7
(S)-(5Z,8Z)-11-[[2-(tert-butyldiphenylsilanyloxy)ethyl](dimethylethoxycarbonyl)amino]tetradeca-5,8-dienoic acid 2-[tert-butoxycarbonyl-((S)-(Z)-10-carboxy-1-propyldec-6-enyl)amino]ethyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 80 percent / NaH / dimethylformamide / 48 h / 0 - 40 °C

2: 77 percent / Ph₂PCH₂CH₂PPh₂; Br₂ / CH₂Cl₂ / 3.5 h / 0 - 20 °C

3: 83 percent / n-BuLi; CuI / tetrahydrofuran; hexane / 27 h / 35 °C

4: 8.5 mg / H₂ / Lindlar catalyst / ethyl acetate; ethanol / 1.5 h

5: 97 percent / Na; naphthalene / 1,2-dimethoxy-ethane / -75 - 20 °C

6: 96 percent / tetrahydrofuran / 17 h / 20 °C

7: 82 percent / NaHSO₄; LiOH / 1,2-dimethoxy-ethane; H₂O / 8 h / 20 °C

8: 76 percent / DMAP; DCC / CH₂Cl₂ / 18 h / 20 °C

9: 80 percent / TBAF / tetrahydrofuran / 2 h

10: 82 percent / DMAP; DCC / CH₂Cl₂ / 4.5 h / 20 °C

11: 93 percent / morpholine; PPh₃ / Pd(OAc)2 / tetrahydrofuran / 7 h

With morpholine; dmap; lithium hydroxide; sodium hydrogen sulfate; copper(l) iodide; n-butyllithium; naphthalene; tetrabutyl ammonium fluoride; hydrogen; bromine; sodium; sodium hydride; dicyclohexyl-carbodiimide; triphenylphosphine; 1,2-bis-(diphenylphosphino)ethane; palladium diacetate; Lindlar's catalyst; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo001200w