(2S,4S)-4-benzyloxy-2-methoxycarbonyl-N-ethoxycarbonylpyrrolidine

Base Information

• Chemical Name: (2S,4S)-4-benzyloxy-2-methoxycarbonyl-N-ethoxycarbonylpyrrolidine
• CAS No.: 791857-01-7
• Molecular Formula: C₁₆H₁₉NO₆
• Molecular Weight: 321.33
• Mol file: 791857-01-7.mol

Synonyms:(2S,4S)-4-benzyloxy-2-methoxycarbonyl-N-ethoxycarbonylpyrrolidine

Chemical Property of (2S,4S)-4-benzyloxy-2-methoxycarbonyl-N-ethoxycarbonylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (2S,4S)-4-benzyloxy-2-methoxycarbonyl-N-ethoxycarbonylpyrrolidine

There total 1 articles about (2S,4S)-4-benzyloxy-2-methoxycarbonyl-N-ethoxycarbonylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzoic acid (65-85-0,8013-63-6) + (2S,4R)-1-ethyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate (172947-80-7) → (2S,4S)-4-benzyloxy-2-methoxycarbonyl-N-ethoxycarbonylpyrrolidine (791857-01-7)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 ℃; for 5h;

DOI:10.1021/jo049375j

Reference yield:

(2S,4S)-4-benzyloxy-2-methoxycarbonyl-N-ethoxycarbonylpyrrolidine (791857-01-7) → (2S,5S,7S)-1-aza-4-hydroxy-2-(diphenylphosphino)phenyl-3-oxa-4,4-diphenylbicyclo[3.3.0]octane

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 5 h / 20 °C

2: 112 mg / KOH / H₂O; methanol / 24 h / 100 °C

3: p-TsOH / benzene / 24 h / Heating

With potassium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water; benzene; 1: Grignard reaction;

DOI:10.1021/jo049375j

Reference yield:

(2S,4S)-4-benzyloxy-2-methoxycarbonyl-N-ethoxycarbonylpyrrolidine (791857-01-7) → (2S,4S)-4-hydroxy-α,α-diphenyl-2-pyrrolidinemethanol (791857-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 5 h / 20 °C

2: 112 mg / KOH / H₂O; methanol / 24 h / 100 °C

With potassium hydroxide; In tetrahydrofuran; methanol; water; 1: Grignard reaction;

DOI:10.1021/jo049375j

upstream raw materials:

benzoic acid

(2S,4R)-1-ethyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

Downstream raw materials:

(2S,4S)-4-hydroxy-α,α-diphenyl-2-pyrrolidinemethanol