5-((3'-(hydroxy)biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide

Base Information

Chemical Name:5-((3'-(hydroxy)biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide
CAS No.:1443159-70-3
Molecular Formula:C₁₇H₁₇N₅O₂
Molecular Weight:323.354
Hs Code.:

Synonyms:5-((3'-(hydroxy)biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide

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Chemical Property of 5-((3'-(hydroxy)biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide

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Technology Process of 5-((3'-(hydroxy)biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide

There total 5 articles about 5-((3'-(hydroxy)biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 5-((3'-(benzyloxy)biphenyl-4-yl)methyl)-1H(2H)-tetrazole

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 1443159-59-8
5-((3'-(hydroxy)biphenyl-4-yl)methyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide

: 1443159-70-3
5-((3'-(hydroxy)biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide

Guidance literature:: 5-((3'-(benzyloxy)biphenyl-4-yl)methyl)-1H(2H)-tetrazole; N,N-Dimethylcarbamoyl chloride; With triethylamine; In acetonitrile; at 0 ℃;

With palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃; for 15h;
DOI:10.1016/j.ejmech.2013.02.005

Reference yield:

: 51628-12-7
4-iodophenylacetonitrile

: 1443159-59-8
5-((3'-(hydroxy)biphenyl-4-yl)methyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide

: 1443159-70-3
5-((3'-(hydroxy)biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate; potassium bromide / 1,4-dioxane / 85 °C / Inert atmosphere

2.1: potassium carbonate / acetone / Reflux

3.1: azido tributyltin (IV) / 1,4-dioxane / Reflux

3.2: 20 °C

4.1: triethylamine / acetonitrile / 0 °C

4.2: 15 h / 20 °C

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; azido tributyltin (IV); potassium bromide; In 1,4-dioxane; acetone; acetonitrile; 1.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.ejmech.2013.02.005

Reference yield:

: 1443159-80-5
2-(3'-hydroxybiphenyl-4-yl)acetonitrile

: 1443159-59-8
5-((3'-(hydroxy)biphenyl-4-yl)methyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide

: 1443159-70-3
5-((3'-(hydroxy)biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / Reflux

2.1: azido tributyltin (IV) / 1,4-dioxane / Reflux

2.2: 20 °C

3.1: triethylamine / acetonitrile / 0 °C

3.2: 15 h / 20 °C

With potassium carbonate; triethylamine; azido tributyltin (IV); In 1,4-dioxane; acetone; acetonitrile;
DOI:10.1016/j.ejmech.2013.02.005