N¹,N¹-dimethyl-N²-(6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidin-4-yl)-4-fluorobenzamidine

Base Information

• Chemical Name: N¹,N¹-dimethyl-N²-(6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidin-4-yl)-4-fluorobenzamidine
• CAS No.: 457072-38-7
• Molecular Formula: C₁₈H₂₁FN₄
• Molecular Weight: 312.39

Synonyms:N¹,N¹-dimethyl-N²-(6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidin-4-yl)-4-fluorobenzamidine

Chemical Property of N¹,N¹-dimethyl-N²-(6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidin-4-yl)-4-fluorobenzamidine

Chemical Property:

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Technology Process of N¹,N¹-dimethyl-N²-(6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidin-4-yl)-4-fluorobenzamidine

There total 1 articles about N¹,N¹-dimethyl-N²-(6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidin-4-yl)-4-fluorobenzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

4-amino-6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidine (457072-65-0) + N,N-dimethyl-4-fluorobenzamide (24167-56-4) → N1,N1-dimethyl-N2-(6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidin-4-yl)-4-fluorobenzamidine (457072-38-7)

Guidance literature:

With triethylamine; trichlorophosphate; In chloroform; for 50h; Reflux;

DOI:10.1002/jhet.1628

Reference yield: 84.0%

N1,N1-dimethyl-N2-(6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidin-4-yl)-4-fluorobenzamidine (457072-38-7) → N-{2-[3-(4-fluorophenyl)[1,2,4]oxadiazol-5-yl]cyclohepten-1-yl}formamide oxime (457072-09-2)

Guidance literature:

With hydroxylamine hydrochloride; In methanol; at 20 ℃; for 20h;

DOI:10.1002/jhet.1628

upstream raw materials:

4-amino-6,7,8,9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidine

N,N-dimethyl-4-fluorobenzamide

Downstream raw materials:

N-{2-[3-(4-fluorophenyl)[1,2,4]oxadiazol-5-yl]cyclohepten-1-yl}formamide oxime

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