4-chloro-2-(4-methoxyphenyl)-1,2-dihydroquinoline-1,3-dicarbaldehyde

Base Information

• Chemical Name: 4-chloro-2-(4-methoxyphenyl)-1,2-dihydroquinoline-1,3-dicarbaldehyde
• CAS No.: 1236385-08-2
• Molecular Formula: C₁₈H₁₄ClNO₃
• Molecular Weight: 327.767
• Mol file: 1236385-08-2.mol

Synonyms:4-chloro-2-(4-methoxyphenyl)-1,2-dihydroquinoline-1,3-dicarbaldehyde

Chemical Property of 4-chloro-2-(4-methoxyphenyl)-1,2-dihydroquinoline-1,3-dicarbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-2-(4-methoxyphenyl)-1,2-dihydroquinoline-1,3-dicarbaldehyde

There total 2 articles about 4-chloro-2-(4-methoxyphenyl)-1,2-dihydroquinoline-1,3-dicarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(4-methoxyphenyl)quinoline (16032-40-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-chloro-2-(4-methoxyphenyl)-1,2-dihydroquinoline-1,3-dicarbaldehyde (1236385-08-2)

Guidance literature:

2-(4-methoxyphenyl)quinoline; N,N-dimethyl-formamide; With trichlorophosphate; at 50 ℃; Cooling with ice;

With water;

DOI:10.1055/s-0029-1219800

Reference yield: 70.0%

2-(4-methoxyphenyl)-2,3-dihydroquinolin-4(1H)-one (144709-08-0,127844-59-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-chloro-2-(4-methoxyphenyl)-1,2-dihydroquinoline-1,3-dicarbaldehyde (1236385-08-2)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; In dichloromethane; at 0 ℃; for 0.25h;

2-(4-methoxyphenyl)-2,3-dihydroquinolin-4(1H)-one; at 60 ℃;

DOI:10.3390/molecules25173791

Reference yield: 89.0%

4-chloro-2-(4-methoxyphenyl)-1,2-dihydroquinoline-1,3-dicarbaldehyde (1236385-08-2) → 4-(4-methoxyphenyl)isoxazolo[4,3-c]quinoline-5(4H)-carbaldehyde (1236385-12-8)

Guidance literature:

With sodium azide; In dimethyl sulfoxide; at 20 ℃; for 0.5h; chemoselective reaction;

DOI:10.1055/s-0029-1219800

upstream raw materials:

2-(4-methoxyphenyl)quinoline

N,N-dimethyl-formamide

2-(4-methoxyphenyl)-2,3-dihydroquinolin-4(1H)-one

Downstream raw materials:

4-(4-methoxyphenyl)isoxazolo[4,3-c]quinoline-5(4H)-carbaldehyde