5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid [2-(5-oxo-hexyl)-oxazol-4-yl]-amide

Base Information

Chemical Name:5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid [2-(5-oxo-hexyl)-oxazol-4-yl]-amide
CAS No.:1258458-47-7
Molecular Formula:C₁₉H₁₈FN₃O₃S
Molecular Weight:387.435
Hs Code.:

Synonyms:5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid [2-(5-oxo-hexyl)-oxazol-4-yl]-amide

Suppliers and Price of 5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid [2-(5-oxo-hexyl)-oxazol-4-yl]-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid [2-(5-oxo-hexyl)-oxazol-4-yl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid [2-(5-oxo-hexyl)-oxazol-4-yl]-amide

There total 9 articles about 5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid [2-(5-oxo-hexyl)-oxazol-4-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258458-85-3
[5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-[2-(5-oxo-hexyl)-oxazol-4-yl]-carbamic acid tert-butyl ester

: 1258458-47-7
5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid [2-(5-oxo-hexyl)-oxazol-4-yl]-amide

Guidance literature:: [5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-[2-(5-oxo-hexyl)-oxazol-4-yl]-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 3128-07-2
6-oxoheptanoic acid

: 1258458-47-7
5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid [2-(5-oxo-hexyl)-oxazol-4-yl]-amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere

1.2: 2 h / -30 - 20 °C / Inert atmosphere

2.1: methoxycarbonylsulfamoyl-triethylammmonium hydroxide / tetrahydrofuran / 2.5 h / -10 - 0 °C / Inert atmosphere; Reflux

3.1: copper(ll) bromide; hexamethylenetetramine; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

5.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 0.5 h / 20 °C / Inert atmosphere

6.1: sodium azide / water; acetone / 1.5 h / 0 °C / Inert atmosphere

7.1: xylene / 0.08 h / 140 °C / Inert atmosphere

7.2: 0.08 h / 140 °C / Inert atmosphere

8.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C / Inert atmosphere

8.2: 2.5 h / 0 - 20 °C / Inert atmosphere

9.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With sodium azide; methoxycarbonylsulfamoyl-triethylammmonium hydroxide; oxalyl dichloride; hexamethylenetetramine; water; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; sodium hydroxide; copper(ll) bromide; isobutyl chloroformate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; acetone; toluene; xylene; 7.1: Curtius Rearrangement;

Reference yield:

: 1047676-31-2
5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid

: 1258458-47-7
5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid [2-(5-oxo-hexyl)-oxazol-4-yl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 0.5 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C / Inert atmosphere

2.2: 2.5 h / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; sodium hydride; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene;