N-tert-butyl-2-<2(R)-hydroxy-4-phenyl-3(S)-((N-(2-quinolylcarbonyl)-2(S)-(3(R)-tetrahydrothiofuranyl)glycinyl)amino)butyl>decahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide

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Chemical Name:N-tert-butyl-2-<2(R)-hydroxy-4-phenyl-3(S)-((N-(2-quinolylcarbonyl)-2(S)-(3(R)-tetrahydrothiofuranyl)glycinyl)amino)butyl>decahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide
CAS No.:150331-87-6
Molecular Formula:C₄₀H₅₃N₅O₄S
Molecular Weight:699.958
Hs Code.:

N-tert-butyl-2-<2(R)-hydroxy-4-phenyl-3(S)-((N-(2-quinolylcarbonyl)-2(S)-(3(R)-tetrahydrothiofuranyl)glycinyl)amino)butyl>decahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide

Synonyms:N-tert-butyl-2-<2(R)-hydroxy-4-phenyl-3(S)-((N-(2-quinolylcarbonyl)-2(S)-(3(R)-tetrahydrothiofuranyl)glycinyl)amino)butyl>decahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide

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Chemical Property of N-tert-butyl-2-<2(R)-hydroxy-4-phenyl-3(S)-((N-(2-quinolylcarbonyl)-2(S)-(3(R)-tetrahydrothiofuranyl)glycinyl)amino)butyl>decahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide

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Technology Process of N-tert-butyl-2-<2(R)-hydroxy-4-phenyl-3(S)-((N-(2-quinolylcarbonyl)-2(S)-(3(R)-tetrahydrothiofuranyl)glycinyl)amino)butyl>decahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide

There total 17 articles about N-tert-butyl-2-<2(R)-hydroxy-4-phenyl-3(S)-((N-(2-quinolylcarbonyl)-2(S)-(3(R)-tetrahydrothiofuranyl)glycinyl)amino)butyl>decahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42238-15-3,22910-59-4,49676-93-9
(2E)-4-phenylbut-2-en-1-ol

: 150331-87-6
N-tert-butyl-2-<2(R)-hydroxy-4-phenyl-3(S)-((N-(2-quinolylcarbonyl)-2(S)-(3(R)-tetrahydrothiofuranyl)glycinyl)amino)butyl>decahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: 10.3 g / 4A molecular sieves, titanium tetraisopropoxide, diethyl D-tartrate, tert-butyl hydroperoxide / CH₂Cl₂; 2,2,4-trimethyl-pentane / 20 h / -22 °C

2: 2.7 g / titanium tetraisopropoxide, azidotrimethylsilane / benzene / 0.25 h / Heating

3: 1.) 2-acetoxyisobutyryl chloride, 2.) NaOMe / 1.) chloroform, RT, 5 h, 2.) THF, RT, 3 h

4: 9.63 g / propan-2-ol / 80 °C

5: 4.68 g / H₂ / 10percent Pd/C / tetrahydrofuran; methanol; acetic acid / 12 h

6: 0.126 g / 1-hydroxybenzotriazole hydrate, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrichloride, triethylamine / dimethylformamide / 12 h / 23 °C

7: H₂ / 5percent Pd/C / tetrahydrofuran

8: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2S,3S)-tartrate; trimethylsilylazide; 4 A molecular sieve; hydrogen; sodium methylate; 2-acetoxy-2-methylpropanoyl chloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; 2,2,4-trimethylpentane; dichloromethane; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; benzene;
DOI:10.1021/jm00068a006

Reference yield:

: 78571-81-0,81096-89-1,85531-71-1,99883-80-4,128575-26-8,116949-62-3
(R,R)-3-(phenylmethyl)oxiranemethanol

: 150331-87-6
N-tert-butyl-2-<2(R)-hydroxy-4-phenyl-3(S)-((N-(2-quinolylcarbonyl)-2(S)-(3(R)-tetrahydrothiofuranyl)glycinyl)amino)butyl>decahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 2.7 g / titanium tetraisopropoxide, azidotrimethylsilane / benzene / 0.25 h / Heating

2: 1.) 2-acetoxyisobutyryl chloride, 2.) NaOMe / 1.) chloroform, RT, 5 h, 2.) THF, RT, 3 h

3: 9.63 g / propan-2-ol / 80 °C

4: 4.68 g / H₂ / 10percent Pd/C / tetrahydrofuran; methanol; acetic acid / 12 h

5: 0.126 g / 1-hydroxybenzotriazole hydrate, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrichloride, triethylamine / dimethylformamide / 12 h / 23 °C

6: H₂ / 5percent Pd/C / tetrahydrofuran

7: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

With titanium(IV) isopropylate; trimethylsilylazide; hydrogen; sodium methylate; 2-acetoxy-2-methylpropanoyl chloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; benzene;
DOI:10.1021/jm00068a006

Reference yield:

: phenylmagnesium bromide

: 150331-87-6
N-tert-butyl-2-<2(R)-hydroxy-4-phenyl-3(S)-((N-(2-quinolylcarbonyl)-2(S)-(3(R)-tetrahydrothiofuranyl)glycinyl)amino)butyl>decahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: 38.9 g / CuCN / tetrahydrofuran; diethyl ether / -78 - 20 °C

2: 10.3 g / 4A molecular sieves, titanium tetraisopropoxide, diethyl D-tartrate, tert-butyl hydroperoxide / CH₂Cl₂; 2,2,4-trimethyl-pentane / 20 h / -22 °C

3: 2.7 g / titanium tetraisopropoxide, azidotrimethylsilane / benzene / 0.25 h / Heating

4: 1.) 2-acetoxyisobutyryl chloride, 2.) NaOMe / 1.) chloroform, RT, 5 h, 2.) THF, RT, 3 h

5: 9.63 g / propan-2-ol / 80 °C

6: 4.68 g / H₂ / 10percent Pd/C / tetrahydrofuran; methanol; acetic acid / 12 h

7: 0.126 g / 1-hydroxybenzotriazole hydrate, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrichloride, triethylamine / dimethylformamide / 12 h / 23 °C

8: H₂ / 5percent Pd/C / tetrahydrofuran

9: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2S,3S)-tartrate; trimethylsilylazide; 4 A molecular sieve; hydrogen; sodium methylate; 2-acetoxy-2-methylpropanoyl chloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; 2,2,4-trimethylpentane; diethyl ether; dichloromethane; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; benzene;
DOI:10.1021/jm00068a006