(S)-4-{(2R,4S,6R)-4,6-Dihydroxy-6-[(R)-3-(4-methoxy-phenyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-hydroxy-1-methyl-propyl ester

Base Information

Chemical Name:(S)-4-{(2R,4S,6R)-4,6-Dihydroxy-6-[(R)-3-(4-methoxy-phenyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-hydroxy-1-methyl-propyl ester
CAS No.:128388-08-9
Molecular Formula:C₂₄H₃₅NO₈S
Molecular Weight:497.61
Hs Code.:

(S)-4-{(2R,4S,6R)-4,6-Dihydroxy-6-[(R)-3-(4-methoxy-phenyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-hydroxy-1-methyl-propyl ester

Synonyms:(S)-4-{(2R,4S,6R)-4,6-Dihydroxy-6-[(R)-3-(4-methoxy-phenyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-hydroxy-1-methyl-propyl ester

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Chemical Property of (S)-4-{(2R,4S,6R)-4,6-Dihydroxy-6-[(R)-3-(4-methoxy-phenyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-hydroxy-1-methyl-propyl ester

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Technology Process of (S)-4-{(2R,4S,6R)-4,6-Dihydroxy-6-[(R)-3-(4-methoxy-phenyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-hydroxy-1-methyl-propyl ester

There total 1 articles about (S)-4-{(2R,4S,6R)-4,6-Dihydroxy-6-[(R)-3-(4-methoxy-phenyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-hydroxy-1-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101860-55-3
((2R,3R,7R,10S)-2,3,10-Trimethyl-1,4,6-trioxa-spiro[4.5]dec-7-yl)-acetaldehyde

: 128359-68-2
(R)-4-Acetyl-3-(4-methoxy-phenyl)-thiazolidin-2-one

: 128443-28-7
(S)-4-{(2R,4R,6R)-4,6-Dihydroxy-6-[(R)-3-(4-methoxy-phenyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-hydroxy-1-methyl-propyl ester

: 128388-08-9
(S)-4-{(2R,4S,6R)-4,6-Dihydroxy-6-[(R)-3-(4-methoxy-phenyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-hydroxy-1-methyl-propyl ester

Guidance literature:: Yield given. Multistep reaction. Yields of byproduct given;
DOI:10.1021/jo00300a006

Reference yield:

: 128388-08-9
(S)-4-{(2R,4S,6R)-4,6-Dihydroxy-6-[(R)-3-(4-methoxy-phenyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-hydroxy-1-methyl-propyl ester

: 76343-93-6
latrunculin A

Guidance literature:: Multi-step reaction with 10 steps

1: CSA / toluene

2: imidazole, DMAP / dimethylformamide

3: LiAlH₄ / tetrahydrofuran / 0 °C

4: 1.) t-BuLi, 2.) O₂ / 1.) THF, -78 deg C

5: PCC/Al₂O₃

6: i-Pr₂NEt, DMAP / CH₂Cl₂

7: 1.) NaN(TMS)2 / 1.) THF, HMPA

8: pyridine*(HF)x / tetrahydrofuran

9: 83 percent / n-Bu₄NF

10: 49 percent / 3 N HCl / tetrahydrofuran

With 1H-imidazole; hydrogenchloride; dmap; aluminum oxide; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; tert.-butyl lithium; oxygen; sodium hexamethyldisilazane; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; camphor-10-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00300a006

Reference yield:

: 128388-08-9
(S)-4-{(2R,4S,6R)-4,6-Dihydroxy-6-[(R)-3-(4-methoxy-phenyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-hydroxy-1-methyl-propyl ester

: 128359-81-9
(R)-4-[(2R,4S,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-4-hydroxy-3-methyl-butyl)-2-methoxy-tetrahydro-pyran-2-yl]-3-(4-methoxy-phenyl)-thiazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: CSA / toluene

2: imidazole, DMAP / dimethylformamide

3: LiAlH₄ / tetrahydrofuran / 0 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; camphor-10-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00300a006