1-(2-(4-chlorobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride

Base Information

Chemical Name:1-(2-(4-chlorobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride
CAS No.:1440858-81-0
Molecular Formula:C₁₉H₁₇ClN₂O₂*ClH
Molecular Weight:377.27
Hs Code.:

Synonyms:1-(2-(4-chlorobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride

Suppliers and Price of 1-(2-(4-chlorobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-(4-chlorobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride

Chemical Property:

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Technology Process of 1-(2-(4-chlorobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride

There total 4 articles about 1-(2-(4-chlorobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 288-32-4
1H-imidazole

: 1440858-10-5
1-(2'-(4-chlorobenzyloxy)phenyl)-3-dimethylamino-1-propanone hydrochloride

: 1440858-81-0
1-(2-(4-chlorobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride

Guidance literature:: 1H-imidazole; 1-(2'-(4-chlorobenzyloxy)phenyl)-3-dimethylamino-1-propanone hydrochloride; In water; for 1h; Reflux;

With hydrogenchloride; In diethyl ether; isopropyl alcohol; at 20 ℃;
DOI:10.1002/ardp.201200287

Reference yield:

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 1440858-81-0
1-(2-(4-chlorobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 0.08 h / 20 °C

1.2: 5 h / Reflux

2.1: hydrogenchloride / isopropyl alcohol; water / Reflux

3.1: water / 1 h / Reflux

3.2: 20 °C

With hydrogenchloride; sodium ethanolate; In ethanol; water; isopropyl alcohol; 2.1: |Mannich Aminomethylation;
DOI:10.1002/ardp.201200287

Reference yield:

: 79615-80-8
1-(2-(4-chlorobenzyloxy)phenyl)ethanone

: 1440858-81-0
1-(2-(4-chlorobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol; water / Reflux

2.1: water / 1 h / Reflux

2.2: 20 °C

With hydrogenchloride; In water; isopropyl alcohol; 1.1: |Mannich Aminomethylation;
DOI:10.1002/ardp.201200287