Indoline-7-sulfonamide

Base Information

• Chemical Name: Indoline-7-sulfonamide
• CAS No.: 111048-65-8
• Molecular Formula: C8H10 N2 O2 S
• Molecular Weight: 198.24
• European Community (EC) Number: 879-313-7
• DSSTox Substance ID: DTXSID601292539
• Mol file: 111048-65-8.mol

Synonyms:indoline-7-sulfonamide;111048-65-8;1H-Indole-7-sulfonamide,2,3-dihydro-(9CI);2,3-DIHYDRO-1H-INDOLE-7-SULFONAMIDE;SCHEMBL566044;HLLIZWSHMLSVLJ-UHFFFAOYSA-N;DTXSID601292539;AKOS027395053;SB65843;EN300-253256;Z1216831226

Chemical Property of Indoline-7-sulfonamide

Chemical Property:

• PSA: 80.57000
• LogP: 2.22110
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 198.04629874
• Heavy Atom Count: 13
• Complexity: 283

Purity/Quality:

98% ^*data from raw suppliers

2,3-Dihydro-1H-indole-7-sulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNC2=C1C=CC=C2S(=O)(=O)N

Technology Process of Indoline-7-sulfonamide

There total 4 articles about Indoline-7-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,5,6-tetrahydropyrrolo<1,2,3-de>-1,2,4-benzothiadiazin-3-one 1,1-dioxide (113162-39-3) → 7-sulfonamide indoline (111048-65-8)

Guidance literature:

With sulfuric acid; In water; at 135 ℃; for 2h;

Reference yield:

1-indoline (496-15-1) → 7-sulfonamide indoline (111048-65-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1 h / -42 - 20 °C

2: aluminum (III) chloride / 1.25 h / 20 - 110 °C

3: sulfuric acid / water / 2 h / 135 °C

With aluminum (III) chloride; sulfuric acid; In water;

Reference yield:

N-((chlorosulfonyl)carbamyl)indoline (89731-80-6) → 7-sulfonamide indoline (111048-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / 1.25 h / 20 - 110 °C

2: sulfuric acid / water / 2 h / 135 °C

With aluminum (III) chloride; sulfuric acid; In water;

upstream raw materials:

2,3,5,6-tetrahydropyrrolo<1,2,3-de>-1,2,4-benzothiadiazin-3-one 1,1-dioxide

1-indoline

N-((chlorosulfonyl)carbamyl)indoline

indole

Downstream raw materials:

1H-indole-7-sulfonamide