6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 4-fluoro-3-(trifluoromethyl)phenyl ketone

Base Information

Chemical Name:6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 4-fluoro-3-(trifluoromethyl)phenyl ketone
CAS No.:193965-27-4
Molecular Formula:C₂₅H₁₉F₄NO₂S
Molecular Weight:473.491
Hs Code.:

Synonyms:6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 4-fluoro-3-(trifluoromethyl)phenyl ketone

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Chemical Property of 6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 4-fluoro-3-(trifluoromethyl)phenyl ketone

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Technology Process of 6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 4-fluoro-3-(trifluoromethyl)phenyl ketone

There total 3 articles about 6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 4-fluoro-3-(trifluoromethyl)phenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 67515-56-4
4-fluoro-3-trifluoromethylbenzoyl chloride

: 193965-55-8
6-benzyloxy-2-(dimethyl-amino)benzo[b]thiophene

: 193965-27-4
6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 4-fluoro-3-(trifluoromethyl)phenyl ketone

Guidance literature:

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 193965-27-4
6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 4-fluoro-3-(trifluoromethyl)phenyl ketone

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / LDA / tetrahydrofuran

2: 70 percent / MeSO₃H / CH₂Cl₂

3: chlorobenzene / 100 °C

With methanesulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; chlorobenzene;
DOI:10.1016/S0960-894X(99)00076-1

Reference yield:

: 193965-54-7
α-(4-benzyloxyphenyl)-α-hydroxy-N,N-dimethylthioacetamide

: 193965-27-4
6-benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 4-fluoro-3-(trifluoromethyl)phenyl ketone

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / MeSO₃H / CH₂Cl₂

2: chlorobenzene / 100 °C

With methanesulfonic acid; In dichloromethane; chlorobenzene;
DOI:10.1016/S0960-894X(99)00076-1