(5S,6R)-2,2-Bis-benzenesulfonyl-5,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,4,5,6,7-hexahydro-1H-indene

Base Information

Chemical Name:(5S,6R)-2,2-Bis-benzenesulfonyl-5,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,4,5,6,7-hexahydro-1H-indene
CAS No.:87432-56-2
Molecular Formula:C₃₅H₅₄O₆S₂Si₂
Molecular Weight:691.113
Hs Code.:

Synonyms:(5S,6R)-2,2-Bis-benzenesulfonyl-5,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,4,5,6,7-hexahydro-1H-indene

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Chemical Property of (5S,6R)-2,2-Bis-benzenesulfonyl-5,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,4,5,6,7-hexahydro-1H-indene

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Technology Process of (5S,6R)-2,2-Bis-benzenesulfonyl-5,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,4,5,6,7-hexahydro-1H-indene

There total 4 articles about (5S,6R)-2,2-Bis-benzenesulfonyl-5,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,4,5,6,7-hexahydro-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 3406-02-8
bis(phenylsulfonyl)methane

: 87432-55-1
(4S,5R)-1,2-Bis-bromomethyl-4,5-bis-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohexene

: 87432-56-2
(5S,6R)-2,2-Bis-benzenesulfonyl-5,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,4,5,6,7-hexahydro-1H-indene

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/ja00360a057

Reference yield:

: 82167-48-4
2,3-bis<(trimethyksilyl)methyl>-1,3-butadiene

: 87432-56-2
(5S,6R)-2,2-Bis-benzenesulfonyl-5,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,4,5,6,7-hexahydro-1H-indene

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) LAH / 1.) PhCH₃, heating, 2.) THF, reflux

2: 99 percent / C₃H₄N₂ / dimethylformamide

3: 1.) cupric bromide, propylene oxide, bromine, 2.) bromine / 1.) CCl₄, THF, -78 deg C, 15 min, to 0 deg C, 15 min, 2.) CCl₄, -78 deg C, 15 min, to 0 deg C, 15 min

4: 80 percent / sodium hydride / dimethylformamide

With lithium aluminium tetrahydride; bromine; sodium hydride; methyloxirane; copper(ll) bromide; In N,N-dimethyl-formamide;
DOI:10.1021/ja00360a057

Reference yield:

: 87413-55-6
((1S,6R)-6-Hydroxymethyl-3,4-bis-trimethylsilanylmethyl-cyclohex-3-enyl)-methanol

: 87432-56-2
(5S,6R)-2,2-Bis-benzenesulfonyl-5,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,4,5,6,7-hexahydro-1H-indene

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / C₃H₄N₂ / dimethylformamide

2: 1.) cupric bromide, propylene oxide, bromine, 2.) bromine / 1.) CCl₄, THF, -78 deg C, 15 min, to 0 deg C, 15 min, 2.) CCl₄, -78 deg C, 15 min, to 0 deg C, 15 min

3: 80 percent / sodium hydride / dimethylformamide

With bromine; sodium hydride; methyloxirane; copper(ll) bromide; In N,N-dimethyl-formamide;
DOI:10.1021/ja00360a057