2-[(1R)-1-({[(6R)-6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-oxazolcarboxylic acid

Base Information

Chemical Name:2-[(1R)-1-({[(6R)-6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-oxazolcarboxylic acid
CAS No.:1444198-69-9
Molecular Formula:C₂₁H₂₃ClN₄O₇
Molecular Weight:478.889
Hs Code.:

Synonyms:2-[(1R)-1-({[(6R)-6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-oxazolcarboxylic acid

Suppliers and Price of 2-[(1R)-1-({[(6R)-6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-oxazolcarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[(1R)-1-({[(6R)-6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-oxazolcarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[(1R)-1-({[(6R)-6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-oxazolcarboxylic acid

There total 22 articles about 2-[(1R)-1-({[(6R)-6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-oxazolcarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₆Cl₄N₄O₁₀

: 1444198-69-9
2-[(1R)-1-({[(6R)-6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-oxazolcarboxylic acid

Guidance literature:: With acetic acid; zinc; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2013.04.079

Reference yield:

: 1312769-89-3
methyl (2S)-2-{[(2R)-2-tert-butoxycarbonylamino]butyrylamino}-3-hydroxypropanoate

: 1444198-69-9
2-[(1R)-1-({[(6R)-6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-oxazolcarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -20 °C

1.2: 6 h / 0 °C

2.1: sodium hydroxide; water / methanol / 3 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 2.5 h / 20 °C

4.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

5.1: dmap; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 0 °C

6.1: acetic acid; zinc / 3 h / 20 °C

With hydrogenchloride; dmap; diethylamino-sulfur trifluoride; water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.079

Reference yield:

: 1312769-90-6
methyl 2-[(1R)-1-(tert-butoxycarbonylamino)propyl]oxazole 4-carboxylate

: 1444198-69-9
2-[(1R)-1-({[(6R)-6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-oxazolcarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; water / methanol / 3 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 2.5 h / 20 °C

3: hydrogenchloride / ethyl acetate / 2 h / 20 °C

4: dmap; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 0 °C

5: acetic acid; zinc / 3 h / 20 °C

With hydrogenchloride; dmap; water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.079