3-methoxy-2-(4-methoxy-phenyl)-3-trimethylsilanyloxy-piperidine-1-carboxylic acid methyl ester

Base Information

• Chemical Name: 3-methoxy-2-(4-methoxy-phenyl)-3-trimethylsilanyloxy-piperidine-1-carboxylic acid methyl ester
• CAS No.: 1025917-47-8
• Molecular Formula: C₁₈H₂₉NO₅Si
• Molecular Weight: 367.517
• Mol file: 1025917-47-8.mol

Synonyms:3-methoxy-2-(4-methoxy-phenyl)-3-trimethylsilanyloxy-piperidine-1-carboxylic acid methyl ester

Chemical Property of 3-methoxy-2-(4-methoxy-phenyl)-3-trimethylsilanyloxy-piperidine-1-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxy-2-(4-methoxy-phenyl)-3-trimethylsilanyloxy-piperidine-1-carboxylic acid methyl ester

There total 2 articles about 3-methoxy-2-(4-methoxy-phenyl)-3-trimethylsilanyloxy-piperidine-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl chloroformate (79-22-1) + 3-methoxy-2-(4-methoxy-phenyl)-3-trimethylsilanyloxy-piperidine → 3-methoxy-2-(4-methoxy-phenyl)-3-trimethylsilanyloxy-piperidine-1-carboxylic acid methyl ester (1025917-47-8)

Guidance literature:

With sodium hydrogencarbonate; In diethyl ether; at 20 ℃; for 1h;

DOI:10.1021/jo0488917

Reference yield:

4-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-butyric acid methyl ester → 3-methoxy-2-(4-methoxy-phenyl)-3-trimethylsilanyloxy-piperidine-1-carboxylic acid methyl ester (1025917-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N; Bu₄NClO₄ / tetrahydrofuran / 20 °C / Electrochemical reaction

2: aq. NaHCO₃ / diethyl ether / 1 h / 20 °C

With tetrabutylammonium perchlorate; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo0488917

Reference yield:

3-methoxy-2-(4-methoxy-phenyl)-3-trimethylsilanyloxy-piperidine-1-carboxylic acid methyl ester (1025917-47-8) → 1-methoxycarbonyl-2-(4-methoxyphenyl)piperidin-3-one (801282-80-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1021/jo0488917

upstream raw materials:

methyl chloroformate

Downstream raw materials:

1-methoxycarbonyl-2-(4-methoxyphenyl)piperidin-3-one