(2S)-1-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)hexadecane

Base Information

• Chemical Name: (2S)-1-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)hexadecane
• CAS No.: 897932-49-9
• Molecular Formula: C₃₄H₅₆O₃Si
• Molecular Weight: 540.902
• Mol file: 897932-49-9.mol

Synonyms:(2S)-1-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)hexadecane

Chemical Property of (2S)-1-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)hexadecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-1-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)hexadecane

There total 3 articles about (2S)-1-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)hexadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2S)-1-(tert-butyldiphenylsilyloxy)hexadecan-2-ol (897932-48-8) + chloromethyl methyl ether (107-30-2) → (2S)-1-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)hexadecane (897932-49-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2006.03.073

Reference yield:

tert-butyl[(2S)-oxiran-2-ylmethoxy]diphenylsilane (106731-74-2,119944-29-5,107033-46-5) → (2S)-1-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)hexadecane (897932-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CuI / tetrahydrofuran / 0.25 h / -30 °C

1.2: 82 percent / tetrahydrofuran / -10 - 0 °C

2.1: 94 percent / DMAP; triethyl amine / CH₂Cl₂ / 24 h / 20 °C

With dmap; copper(l) iodide; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tet.2006.03.073

Reference yield:

tridecylmagnesium bromide (117711-00-9) → (2S)-1-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)hexadecane (897932-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CuI / tetrahydrofuran / 0.25 h / -30 °C

1.2: 82 percent / tetrahydrofuran / -10 - 0 °C

2.1: 94 percent / DMAP; triethyl amine / CH₂Cl₂ / 24 h / 20 °C

With dmap; copper(l) iodide; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tet.2006.03.073

upstream raw materials:

(2S)-1-(tert-butyldiphenylsilyloxy)hexadecan-2-ol

chloromethyl methyl ether

tert-butyl[(2S)-oxiran-2-ylmethoxy]diphenylsilane

tridecylmagnesium bromide