6-<4-(diethylamino)phenyl>-4-methyl-2-pyridinecarboxylic acid hydrochloride

Base Information

Chemical Name:6-<4-(diethylamino)phenyl>-4-methyl-2-pyridinecarboxylic acid hydrochloride
CAS No.:80021-75-6
Molecular Formula:C₁₇H₂₀N₂O₂*ClH
Molecular Weight:320.819
Hs Code.:

Synonyms:6-<4-(diethylamino)phenyl>-4-methyl-2-pyridinecarboxylic acid hydrochloride

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Chemical Property of 6-<4-(diethylamino)phenyl>-4-methyl-2-pyridinecarboxylic acid hydrochloride

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Technology Process of 6-<4-(diethylamino)phenyl>-4-methyl-2-pyridinecarboxylic acid hydrochloride

There total 7 articles about 6-<4-(diethylamino)phenyl>-4-methyl-2-pyridinecarboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 6-(4-Diethylamino-phenyl)-4-methyl-pyridine-2-carboxylic acid ethyl ester

: 80021-75-6
6-<4-(diethylamino)phenyl>-4-methyl-2-pyridinecarboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; at 80 ℃; for 5h;
DOI:10.1021/jm00364a026

Reference yield:

: 20807-64-1
4-methyl-2-(4-nitrophenyl)pyridine

: 80021-75-6
6-<4-(diethylamino)phenyl>-4-methyl-2-pyridinecarboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 30percent aq. H₂O₂ / acetic acid / 20 h / 80 °C

2: 1.) Me₂SO₄ / 1.) 80-90 deg C, 2 h, 2.) dioxane, H₂O, RT, 30 min

3: 5 M aq. HCl / 11 h / Heating

4: H₂, AcONa / 10percent Pd/C / dimethylformamide

5: SOCl₂ / 4 h / Heating

6: 69.6 percent / K₂CO₃ / dimethylformamide / a) 50 deg C, 0.5 h, b) 100 deg C, 3 h

7: 100 percent / 8percent aq. HCl / 5 h / 80 °C

With hydrogenchloride; thionyl chloride; hydrogen; dihydrogen peroxide; sodium acetate; potassium carbonate; dimethyl sulfate; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026

Reference yield:

: 80021-65-4
4-methyl-2-(4-nitrophenyl)pyridine N-oxide

: 80021-75-6
6-<4-(diethylamino)phenyl>-4-methyl-2-pyridinecarboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Me₂SO₄ / 1.) 80-90 deg C, 2 h, 2.) dioxane, H₂O, RT, 30 min

2: 5 M aq. HCl / 11 h / Heating

3: H₂, AcONa / 10percent Pd/C / dimethylformamide

4: SOCl₂ / 4 h / Heating

5: 69.6 percent / K₂CO₃ / dimethylformamide / a) 50 deg C, 0.5 h, b) 100 deg C, 3 h

6: 100 percent / 8percent aq. HCl / 5 h / 80 °C

With hydrogenchloride; thionyl chloride; hydrogen; sodium acetate; potassium carbonate; dimethyl sulfate; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026