[1R,2S,SS]-N-[1,2-(diphenyl)-2-(methylthio)ethyl]-p-toluene sulfinamide

Base Information

Chemical Name:[1R,2S,SS]-N-[1,2-(diphenyl)-2-(methylthio)ethyl]-p-toluene sulfinamide
CAS No.:852333-02-9
Molecular Formula:C₂₂H₂₃NOS₂
Molecular Weight:381.563
Hs Code.:

Synonyms:[1R,2S,SS]-N-[1,2-(diphenyl)-2-(methylthio)ethyl]-p-toluene sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [1R,2S,SS]-N-[1,2-(diphenyl)-2-(methylthio)ethyl]-p-toluene sulfinamide

Chemical Property:

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Technology Process of [1R,2S,SS]-N-[1,2-(diphenyl)-2-(methylthio)ethyl]-p-toluene sulfinamide

There total 4 articles about [1R,2S,SS]-N-[1,2-(diphenyl)-2-(methylthio)ethyl]-p-toluene sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 852332-86-6
[1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-(methylthio)ethyl}-p-toluenesulfinamide

: 852333-02-9
[1R,2S,SS]-N-[1,2-(diphenyl)-2-(methylthio)ethyl]-p-toluene sulfinamide

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; hexane; for 0.0833333h;
DOI:10.1021/jo050129x

Reference yield:

: 852332-84-4
(S)-α-(methylsulfenyl)-2-(p-tolylsulfinyl)toluene

: 852333-02-9
[1R,2S,SS]-N-[1,2-(diphenyl)-2-(methylthio)ethyl]-p-toluene sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1: LDA / -78 °C

2: 100 percent / t-BuLi / tetrahydrofuran; hexane / 0.08 h / -78 °C

With tert.-butyl lithium; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2006.06.072

Reference yield:

: 10381-68-7,42872-16-2,78821-95-1,1517-78-8
(S)-2-methyl-1-(p-tolylsulfinyl)benzene

: 852333-02-9
[1R,2S,SS]-N-[1,2-(diphenyl)-2-(methylthio)ethyl]-p-toluene sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran; hexane / -78 °C

1.2: 70 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.1: LDA / tetrahydrofuran; hexane / 0.08 h / -78 °C

2.2: 85 percent / tetrahydrofuran; hexane / -78 °C

3.1: 100 percent / t-BuLi / tetrahydrofuran; hexane / 0.08 h

With tert.-butyl lithium; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1021/jo050129x