methyl 3-{4-[5-(hydroxyl-methyl)pyrazin-2-yl]phenoxy}-2,2-dimethylpropanoate

Base Information

Chemical Name:methyl 3-{4-[5-(hydroxyl-methyl)pyrazin-2-yl]phenoxy}-2,2-dimethylpropanoate
CAS No.:1382998-99-3
Molecular Formula:C₁₇H₂₀N₂O₄
Molecular Weight:316.357
Hs Code.:

Synonyms:methyl 3-{4-[5-(hydroxyl-methyl)pyrazin-2-yl]phenoxy}-2,2-dimethylpropanoate

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Chemical Property of methyl 3-{4-[5-(hydroxyl-methyl)pyrazin-2-yl]phenoxy}-2,2-dimethylpropanoate

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Technology Process of methyl 3-{4-[5-(hydroxyl-methyl)pyrazin-2-yl]phenoxy}-2,2-dimethylpropanoate

There total 5 articles about methyl 3-{4-[5-(hydroxyl-methyl)pyrazin-2-yl]phenoxy}-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72788-94-4
(5-chloro-2-pyrazinyl)methanol

: 1382998-92-6
methyl 2,2-dimethyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propanoate

: 1382998-99-3
methyl 3-{4-[5-(hydroxyl-methyl)pyrazin-2-yl]phenoxy}-2,2-dimethylpropanoate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl acetamide; water; at 80 ℃;

Reference yield:

: 33332-25-1
methyl 5-chloropyrazine-2-carboxylate

: 1382998-99-3
methyl 3-{4-[5-(hydroxyl-methyl)pyrazin-2-yl]phenoxy}-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 0.25 h / 0 °C

1.3: pH 7

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl acetamide; water / 80 °C

With diisobutylaluminium hydride; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; N,N-dimethyl acetamide; water;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1382998-99-3
methyl 3-{4-[5-(hydroxyl-methyl)pyrazin-2-yl]phenoxy}-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 3 h / 70 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 80 °C / Inert atmosphere

3: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl acetamide; water / 80 °C

With potassium acetate; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide; water; toluene;