2-tert-butyl-1-oxo-3-phenyl-2,7-diaza-spiro[3.5]nona-5,8-diene-7-carboxylic acid methyl ester

Base Information

• Chemical Name: 2-tert-butyl-1-oxo-3-phenyl-2,7-diaza-spiro[3.5]nona-5,8-diene-7-carboxylic acid methyl ester
• CAS No.: 864348-15-2
• Molecular Formula: C₁₉H₂₂N₂O₃
• Molecular Weight: 326.395
• Mol file: 864348-15-2.mol

Synonyms:2-tert-butyl-1-oxo-3-phenyl-2,7-diaza-spiro[3.5]nona-5,8-diene-7-carboxylic acid methyl ester

Chemical Property of 2-tert-butyl-1-oxo-3-phenyl-2,7-diaza-spiro[3.5]nona-5,8-diene-7-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-tert-butyl-1-oxo-3-phenyl-2,7-diaza-spiro[3.5]nona-5,8-diene-7-carboxylic acid methyl ester

There total 1 articles about 2-tert-butyl-1-oxo-3-phenyl-2,7-diaza-spiro[3.5]nona-5,8-diene-7-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-benzyl-N-tert-butyl-isonicotinamide + methyl chloroformate (79-22-1) → 2-tert-butyl-1-oxo-3-phenyl-2,7-diaza-spiro[3.5]nona-5,8-diene-7-carboxylic acid methyl ester (864348-15-2)

Guidance literature:

N-benzyl-N-tert-butyl-isonicotinamide; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -40 ℃; for 0.5h;

methyl chloroformate; In tetrahydrofuran;

DOI:10.1021/ol051214u

Reference yield: 97.0%

2-tert-butyl-1-oxo-3-phenyl-2,7-diaza-spiro[3.5]nona-5,8-diene-7-carboxylic acid methyl ester (864348-15-2) → 2-tert-butyl-1-oxo-3-phenyl-2,7-diaza-spiro[3.5]nonane-7-carboxylic acid methyl ester

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 16h; under 760 Torr;

DOI:10.1021/ol051214u

Reference yield: 58.0%

2-tert-butyl-1-oxo-3-phenyl-2,7-diaza-spiro[3.5]nona-5,8-diene-7-carboxylic acid methyl ester (864348-15-2) → methyl (E)-2-(1-tert-butyl-3-formyl-2-oxo-4-phenylazetidin-3-yl)vinylformylcarbamate

Guidance literature:

2-tert-butyl-1-oxo-3-phenyl-2,7-diaza-spiro[3.5]nona-5,8-diene-7-carboxylic acid methyl ester; With ozone; In dichloromethane; at -78 ℃;

With dimethylsulfide; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/ol051214u

upstream raw materials:

methyl chloroformate