(2S,6S)-6-Methoxycarbonylmethyl-5-oxo-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester

Base Information

Chemical Name:(2S,6S)-6-Methoxycarbonylmethyl-5-oxo-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester
CAS No.:145967-54-0
Molecular Formula:C₁₃H₂₀N₂O₇
Molecular Weight:316.311
Hs Code.:

Synonyms:(2S,6S)-6-Methoxycarbonylmethyl-5-oxo-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester

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Chemical Property of (2S,6S)-6-Methoxycarbonylmethyl-5-oxo-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester

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Technology Process of (2S,6S)-6-Methoxycarbonylmethyl-5-oxo-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester

There total 4 articles about (2S,6S)-6-Methoxycarbonylmethyl-5-oxo-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70681-41-3
(R)-dimethyl malate

: 145967-54-0
(2S,6S)-6-Methoxycarbonylmethyl-5-oxo-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1) (CF₃SO₂)2, 2) 2,6-lutidine / 1) CH₂Cl₂, -78 deg C, 5 min 2) CH₂Cl₂, -78 deg C to r.t., 18h

2: 85 percent / Ph₃P / tetrahydrofuran; H₂O / 72 h / Ambient temperature

3: H₂ / 10percent Pd/C

4: NaHCO₃ / dioxane; H₂O

With 2,6-dimethylpyridine; (CF₃SO₂)2; hydrogen; sodium hydrogencarbonate; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1016/S0040-4039(00)60843-2

Reference yield:

: 146075-58-3
(2S,6R)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester

: 145967-54-0
(2S,6S)-6-Methoxycarbonylmethyl-5-oxo-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C

2: NaHCO₃ / dioxane; H₂O

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In 1,4-dioxane; water;
DOI:10.1016/S0040-4039(00)60843-2

Reference yield:

: (S)-2-((R)-2-Azido-1-benzyloxycarbonyl-ethylamino)-succinic acid dimethyl ester

: 145967-54-0
(2S,6S)-6-Methoxycarbonylmethyl-5-oxo-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / Ph₃P / tetrahydrofuran; H₂O / 72 h / Ambient temperature

2: H₂ / 10percent Pd/C

3: NaHCO₃ / dioxane; H₂O

With hydrogen; sodium hydrogencarbonate; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1016/S0040-4039(00)60843-2