2-(2-(diphenylphosphoryl)phenyl)-5,5-dimethyl-4-(naphthalen-1-yl)-4,5-dihydrooxazole

Base Information

Chemical Name:2-(2-(diphenylphosphoryl)phenyl)-5,5-dimethyl-4-(naphthalen-1-yl)-4,5-dihydrooxazole
CAS No.:1284239-90-2
Molecular Formula:C₃₃H₂₈NO₂P
Molecular Weight:501.565
Hs Code.:

Synonyms:2-(2-(diphenylphosphoryl)phenyl)-5,5-dimethyl-4-(naphthalen-1-yl)-4,5-dihydrooxazole

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Chemical Property of 2-(2-(diphenylphosphoryl)phenyl)-5,5-dimethyl-4-(naphthalen-1-yl)-4,5-dihydrooxazole

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Technology Process of 2-(2-(diphenylphosphoryl)phenyl)-5,5-dimethyl-4-(naphthalen-1-yl)-4,5-dihydrooxazole

There total 5 articles about 2-(2-(diphenylphosphoryl)phenyl)-5,5-dimethyl-4-(naphthalen-1-yl)-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1284239-86-6
5,5-dimethyl-4-(naphthalen-1-yl)-2-phenyl-4,5-dihydrooxazole

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 1284239-90-2
2-(2-(diphenylphosphoryl)phenyl)-5,5-dimethyl-4-(naphthalen-1-yl)-4,5-dihydrooxazole

Guidance literature:: 5,5-dimethyl-4-(naphthalen-1-yl)-2-phenyl-4,5-dihydrooxazole; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 - 0 ℃; for 1.66667h; Inert atmosphere;

chloro-diphenylphosphine; In tetrahydrofuran; cyclohexane; at 0 - 20 ℃; Inert atmosphere;

With dihydrogen peroxide; In tetrahydrofuran; cyclohexane; water; for 0.333333h; Inert atmosphere;
DOI:10.1021/ja111700e

Reference yield:

: 1284239-83-3
2,2-dimethyl-3-(naphthalen-1-yl)oxirane

: 1284239-90-2
2-(2-(diphenylphosphoryl)phenyl)-5,5-dimethyl-4-(naphthalen-1-yl)-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron trifluoride diethyl etherate / 0 - 20 °C / Inert atmosphere

2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1.67 h / -78 - 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

2.3: 0.33 h / Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; boron trifluoride diethyl etherate; sec.-butyllithium; In tetrahydrofuran; cyclohexane;
DOI:10.1021/ja111700e

Reference yield:

: 29926-68-9
1-(β,β-dimethylvinyl)naphthalene

: 1284239-90-2
2-(2-(diphenylphosphoryl)phenyl)-5,5-dimethyl-4-(naphthalen-1-yl)-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C / Inert atmosphere

2.1: boron trifluoride diethyl etherate / 0 - 20 °C / Inert atmosphere

3.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1.67 h / -78 - 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

3.3: 0.33 h / Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; boron trifluoride diethyl etherate; sec.-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; cyclohexane;
DOI:10.1021/ja111700e