4-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 4-methyl-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 110841-71-9
• Molecular Formula: C10H13 N
• Molecular Weight: 147.22
• Hs Code.: 2933499090
• Mol file: 110841-71-9.mol

Synonyms:1,2,3,4-Tetrahydro-4-methylisoquinoline;4-Methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 4-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

• PSA: 12.03000
• LogP: 2.22210
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Methyl-1,2,3,4-tetrahydroisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methyl-1,2,3,4-tetrahydroisoquinoline can be prepared as ABHD6 and dual ABHD6/MGL inhibitors.

Technology Process of 4-methyl-1,2,3,4-tetrahydroisoquinoline

There total 9 articles about 4-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-methyl-3,4-dihydro-2H-isoquinolin-1-one (70079-42-4) → 4-methyl-1,2,3,4-tetrahydro-isoquinoline (110841-71-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 24h; Heating;

DOI:10.1021/jm00397a029

Reference yield: 77.0%

4-methyl-3,4-dihydro-isoquinoline (86457-01-4) → 4-methyl-1,2,3,4-tetrahydro-isoquinoline (110841-71-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 1h; Heating;

DOI:10.1021/jo971257r

Reference yield: 61.0%

Allylbenzylamine (4383-22-6) → 4-methyl-1,2,3,4-tetrahydro-isoquinoline (110841-71-9)

Guidance literature:

With PPA; In chloroform; at 180 ℃; for 2h;

upstream raw materials:

Allylbenzylamine

4-methyl-3,4-dihydro-2H-isoquinolin-1-one

4-methylisoquinoline

4-methyl-3,4-dihydro-isoquinoline

Downstream raw materials:

4-methyl-3,4-dihydro-2H-isoquinolin-1-one

N-benzoyl-4-methyl-1,2,3,4-tetrahydroisoquinoline

Refernces

• 1、 Grunewald,Sall,Monn. "Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines". . p. 433 - 444. Retrieved 1988.
• 2、 -. "Macrocyclic compounds as inhibitors of viral replication". . . Retrieved 2008/06/13.
• 3、 -. "Tetrahydroisoquinoline derivative and medical preparation containing the same". . . Retrieved 2008/06/13.