((R)-1-Naphthalen-1-yl-ethyl)-carbamic acid (R)-5-(4-hydroxy-phenyl)-1-[2-(4-hydroxy-phenyl)-ethyl]-pentyl ester

Base Information

• Chemical Name: ((R)-1-Naphthalen-1-yl-ethyl)-carbamic acid (R)-5-(4-hydroxy-phenyl)-1-[2-(4-hydroxy-phenyl)-ethyl]-pentyl ester
• CAS No.: 777059-73-1
• Molecular Formula: C₃₂H₃₅NO₄
• Molecular Weight: 497.634
• Mol file: 777059-73-1.mol

Synonyms:((R)-1-Naphthalen-1-yl-ethyl)-carbamic acid (R)-5-(4-hydroxy-phenyl)-1-[2-(4-hydroxy-phenyl)-ethyl]-pentyl ester

Chemical Property of ((R)-1-Naphthalen-1-yl-ethyl)-carbamic acid (R)-5-(4-hydroxy-phenyl)-1-[2-(4-hydroxy-phenyl)-ethyl]-pentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((R)-1-Naphthalen-1-yl-ethyl)-carbamic acid (R)-5-(4-hydroxy-phenyl)-1-[2-(4-hydroxy-phenyl)-ethyl]-pentyl ester

There total 4 articles about ((R)-1-Naphthalen-1-yl-ethyl)-carbamic acid (R)-5-(4-hydroxy-phenyl)-1-[2-(4-hydroxy-phenyl)-ethyl]-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-(1-naphthyl)ethyl isocyanate (42340-98-7) + 1,7-bis-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-heptan-3-ol (777059-70-8) → ((S)-1-Naphthalen-1-yl-ethyl)-carbamic acid (S)-5-(4-hydroxy-phenyl)-1-[2-(4-hydroxy-phenyl)-ethyl]-pentyl ester + ((R)-1-Naphthalen-1-yl-ethyl)-carbamic acid (R)-5-(4-hydroxy-phenyl)-1-[2-(4-hydroxy-phenyl)-ethyl]-pentyl ester (777059-73-1)

Guidance literature:

With boron trifluoride; In diethyl ether; at 20 ℃; for 1.5h;

DOI:10.1021/jf040135e

Reference yield:

4-(tetrahydropyran-2'-yloxy)-1-bromobenzene (36603-49-3) → ((R)-1-Naphthalen-1-yl-ethyl)-carbamic acid (R)-5-(4-hydroxy-phenyl)-1-[2-(4-hydroxy-phenyl)-ethyl]-pentyl ester (777059-73-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Mg / tetrahydrofuran

1.2: 71 percent / CuBr; LiBr / tetrahydrofuran / 1.5 h / 50 °C

2.1: Mg / tetrahydrofuran

2.2: tetrahydrofuran / 1 h

3.1: 0.731 g / BF₃ / diethyl ether / 1.5 h / 20 °C

With boron trifluoride; magnesium; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jf040135e

Reference yield:

4-bromo-phenol (106-41-2) → ((R)-1-Naphthalen-1-yl-ethyl)-carbamic acid (R)-5-(4-hydroxy-phenyl)-1-[2-(4-hydroxy-phenyl)-ethyl]-pentyl ester (777059-73-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 98 percent / p-toluenesulfonic acid / CH₂Cl₂ / 1 h / 20 °C

2.1: Mg / tetrahydrofuran

2.2: 71 percent / CuBr; LiBr / tetrahydrofuran / 1.5 h / 50 °C

3.1: Mg / tetrahydrofuran

3.2: tetrahydrofuran / 1 h

4.1: 0.731 g / BF₃ / diethyl ether / 1.5 h / 20 °C

With boron trifluoride; toluene-4-sulfonic acid; magnesium; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/jf040135e

upstream raw materials:

(R)-1-(1-naphthyl)ethyl isocyanate

1,7-bis-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-heptan-3-ol

4-(tetrahydropyran-2'-yloxy)-1-bromobenzene

4-bromo-phenol

Downstream raw materials:

(3R)-1,7-bis(4'-hydroxyphenyl)-3-heptanol

Refernces