methyl 2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoate

Base Information

Chemical Name:methyl 2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoate
CAS No.:1141474-97-6
Molecular Formula:C₂₅H₂₁FN₂O₄
Molecular Weight:432.451
Hs Code.:

Synonyms:methyl 2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoate

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Chemical Property of methyl 2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoate

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Technology Process of methyl 2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoate

There total 8 articles about methyl 2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 918967-55-2
methyl 4-[amino(hydroxyimino)methyl]-2-fluorobenzoate

: 1141473-83-7
2-(methoxymethyl)-2’-methyl biphenyl-4-carboxylic acid

: 1141474-97-6
methyl 2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoate

Guidance literature:: 2-(methoxymethyl)-2’-methyl biphenyl-4-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In toluene; at 20 ℃; for 3h;

methyl 4-[amino(hydroxyimino)methyl]-2-fluorobenzoate; With pyridine; In toluene; at 20 ℃; for 36h; Heating / reflux;

Reference yield:

: 918967-55-2
methyl 4-[amino(hydroxyimino)methyl]-2-fluorobenzoate

: 1141475-66-2
2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl chloride

: 1141474-97-6
methyl 2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoate

Guidance literature:: With pyridine; In toluene; at 20 ℃; for 36h; Inert atmosphere; Reflux;
DOI:10.1002/cmdc.201402557

Reference yield:

: 148547-19-7
4-Bromo-3-methylbenzoic acid methyl ester

: 1141474-97-6
methyl 2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chloroform / 48 h / 70 °C / Inert atmosphere

2: 96 h / Reflux

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 1 h / 110 °C / Inert atmosphere

4: sodium hydroxide / ethanol / 1 h / 60 °C

5: oxalyl dichloride / toluene; N,N-dimethyl-formamide / 3 h / 20 °C

6: pyridine / toluene / 36 h / 20 °C / Inert atmosphere; Reflux

With pyridine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); potassium carbonate; sodium hydroxide; In ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201402557