4(5H)-oxo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-pyrazolo<3,4-d>pyrimidine-3-carbonitrile

Base Information

• Chemical Name: 4(5H)-oxo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-pyrazolo<3,4-d>pyrimidine-3-carbonitrile
• CAS No.: 90914-33-3
• Molecular Formula: C₃₂H₂₃N₅O₈
• Molecular Weight: 605.563
• Mol file: 90914-33-3.mol

Synonyms:4(5H)-oxo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-pyrazolo<3,4-d>pyrimidine-3-carbonitrile

Chemical Property of 4(5H)-oxo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-pyrazolo<3,4-d>pyrimidine-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4(5H)-oxo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-pyrazolo<3,4-d>pyrimidine-3-carbonitrile

There total 3 articles about 4(5H)-oxo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-pyrazolo<3,4-d>pyrimidine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

3-cyanoallopurinol (5387-84-8) + 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (14215-97-5) → 4(5H)-oxo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-pyrazolo<3,4-d>pyrimidine-3-carbonitrile (90914-33-3)

Guidance literature:

With boron trifluoride diethyl etherate; In nitrobenzene; for 0.25h;

DOI:10.1021/jm00375a006

Reference yield:

3-cyanoallopurinol (5387-84-8) → 4(5H)-oxo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-pyrazolo<3,4-d>pyrimidine-3-carbonitrile (90914-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: (NH₄)2SO₄, pyridine / 4 h / Heating

2: TMS-triflate / acetonitrile / 168 h / Heating

With pyridine; ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; In acetonitrile;

DOI:10.1021/jm00375a006

Reference yield:

4-Trimethylsilanyloxy-1H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile + 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (14215-97-5) → 4(5H)-oxo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-pyrazolo<3,4-d>pyrimidine-3-carbonitrile (90914-33-3)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; for 168h; Yield given; Heating;

DOI:10.1021/jm00375a006

upstream raw materials:

3-cyanoallopurinol

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose

Downstream raw materials:

4(5H)-oxo-1-β-D-ribofuranosylpyrazolo<3,4-d>pyrimidine-3-thiocarboxamide

C₃₂H₂₃N₅O₇S

4(5H)-oxo-1-β-D-ribofuranosylpyrazolo<3,4-d>pyrimidine-3-carboxamidine hydrochloride