N-(3-Hydroxyphenyl)-D-ribosylamine

Base Information

• Chemical Name: N-(3-Hydroxyphenyl)-D-ribosylamine
• CAS No.: 71415-46-8
• Molecular Formula: C₁₁H₁₅NO₅
• Molecular Weight: 241.244
• Mol file: 71415-46-8.mol

Synonyms:N-(3-Hydroxyphenyl)-D-ribosylamine

Chemical Property of N-(3-Hydroxyphenyl)-D-ribosylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-Hydroxyphenyl)-D-ribosylamine

There total 1 articles about N-(3-Hydroxyphenyl)-D-ribosylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

D-Ribose (532-20-7,613-83-2,7261-25-8,7687-39-0,13221-22-2,14795-83-6,15761-67-8,20074-49-1,25545-03-3,25545-04-4,32445-75-3,34436-17-4,36441-93-7,36468-53-8,37110-85-3,37388-49-1,38029-69-5,40461-77-6,40461-89-0,41546-19-4,41546-20-7,41546-21-8,41546-26-3,41546-29-6,41546-30-9,41546-31-0,126872-16-0,131064-98-7) + m-Hydroxyaniline (591-27-5) → N-(3-Hydroxyphenyl)-D-ribosylamine (71415-46-8)

Guidance literature:

In methanol; for 4h; Heating;

DOI:10.1002/jhet.5570170813

Reference yield: 80.0%

N-(3-Hydroxyphenyl)-D-ribosylamine (71415-46-8) → 1-Deoxy-1-<(3-hydroxyphenyl)amino>-D-ribitol (71415-47-9)

Guidance literature:

With sodium cyanoborohydride; In methanol; acetic acid; for 16h; Ambient temperature;

DOI:10.1002/jhet.5570170813

Reference yield:

N-(3-Hydroxyphenyl)-D-ribosylamine (71415-46-8) → 8-hydroxy-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (37333-48-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / sodium cyanoborohydride / acetic acid; methanol / 16 h / Ambient temperature

2: 70 percent Turnov_. / H₂O / 14 h / Heating

3: 41 percent / p-toluenesulfonic acid monohydrate / 18 h / Heating

4: 83 percent / 1N HCl / H₂O / Heating

With hydrogenchloride; sodium cyanoborohydride; toluene-4-sulfonic acid; In methanol; water; acetic acid;

DOI:10.1002/jhet.5570170813

upstream raw materials:

D-Ribose

m-Hydroxyaniline

Downstream raw materials:

1-Deoxy-1-<(3-hydroxyphenyl)amino>-D-ribitol

1-Deoxy-1-<(3-hydroxyphenyl)(1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinyl)amino>-D-ribitol

8-hydroxy-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione

Refernces