N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-asparginamide

Base Information

Chemical Name:N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-asparginamide
CAS No.:164364-46-9
Molecular Formula:C₁₈H₂₃N₃O₅
Molecular Weight:361.398
Hs Code.:

Synonyms:N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-asparginamide

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Chemical Property of N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-asparginamide

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Technology Process of N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-asparginamide

There total 4 articles about N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-asparginamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 57471-69-9
L-asparaginamide hydrochloride

: 151927-79-6
2-(2-(benzyloxy)-2-oxoethyl)-3-methylbut-2-enoic acid

: 164364-46-9
N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-asparginamide

: 2-[((S)-1,2-Dicarbamoyl-ethylcarbamoyl)-methyl]-3-methyl-but-2-enoic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 47h;
DOI:10.1021/jm00012a011

Reference yield:

: 74222-68-7
dihydro-3-(methylethylidene)-2,5-furandione

: 164364-46-9
N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-asparginamide

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / CHCl₃ / 72 h / Heating

2: 28 percent / iPr₂NEt, HOBt-H₂O, EDC / dimethylformamide / 47 h / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00012a011

Reference yield:

: 584-27-0
2-isopropylidenesuccinic acid

: 164364-46-9
N-<2-(methylethylidene)-1,4-dioxo-4-(phenylmethoxy)butyl>-L-asparginamide

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / acetyl chloride / 0.33 h / Heating

2: 69 percent / CHCl₃ / 72 h / Heating

3: 28 percent / iPr₂NEt, HOBt-H₂O, EDC / dimethylformamide / 47 h / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; acetyl chloride; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00012a011