methyl (2R,3S)-(E)-2-[(S)-hydroxyphenylmethyl]-3-phenyl-5-trimethylsilyl4-pentenoate

Base Information

Chemical Name:methyl (2R,3S)-(E)-2-[(S)-hydroxyphenylmethyl]-3-phenyl-5-trimethylsilyl4-pentenoate
CAS No.:264613-83-4
Molecular Formula:C₂₂H₂₈O₃Si
Molecular Weight:368.548
Hs Code.:

Synonyms:methyl (2R,3S)-(E)-2-[(S)-hydroxyphenylmethyl]-3-phenyl-5-trimethylsilyl4-pentenoate

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Chemical Property of methyl (2R,3S)-(E)-2-[(S)-hydroxyphenylmethyl]-3-phenyl-5-trimethylsilyl4-pentenoate

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Technology Process of methyl (2R,3S)-(E)-2-[(S)-hydroxyphenylmethyl]-3-phenyl-5-trimethylsilyl4-pentenoate

There total 3 articles about methyl (2R,3S)-(E)-2-[(S)-hydroxyphenylmethyl]-3-phenyl-5-trimethylsilyl4-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 264613-79-8
methyl (R_S,2R,3R,4R)-3-phenyl-2-[(S)-phenylhydroxymethyl]-4-(p-tolylsulfinyl)-5-trimethylsilylpentanoate

: methyl (2R,3S)-(Z)-2-[(S)-hydroxyphenylmethyl]-3-phenyl-5-trimethylsilyl4-pentenoate

: 264613-83-4
methyl (2R,3S)-(E)-2-[(S)-hydroxyphenylmethyl]-3-phenyl-5-trimethylsilyl4-pentenoate

Guidance literature:: With pyridine; In benzene; for 1h; Heating;
DOI:10.1021/jo991635n

Reference yield:

: 103-26-4,1754-62-7
Methyl cinnamate

: 264613-83-4
methyl (2R,3S)-(E)-2-[(S)-hydroxyphenylmethyl]-3-phenyl-5-trimethylsilyl4-pentenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.25 h / -78 °C

1.2: 98 percent / tetrahydrofuran / 1 h / -78 - 0 °C

2.1: 94 percent / pyridine / benzene / 1 h / Heating

With pyridine; In tetrahydrofuran; benzene; 1.1: Addition / 1.2: Addition / 2.1: Elimination;
DOI:10.1021/jo991635n

Reference yield:

: p-tolyl α-lithio-β-(trimethylsilyl)ethyl sulfoxide

: 264613-83-4
methyl (2R,3S)-(E)-2-[(S)-hydroxyphenylmethyl]-3-phenyl-5-trimethylsilyl4-pentenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.25 h / -78 °C

1.2: 98 percent / tetrahydrofuran / 1 h / -78 - 0 °C

2.1: 94 percent / pyridine / benzene / 1 h / Heating

With pyridine; In tetrahydrofuran; benzene; 1.1: Addition / 1.2: Addition / 2.1: Elimination;
DOI:10.1021/jo991635n