(S)-N¹-((S)-3-Benzylcarbamoyl-3,3-difluoro-2-hydroxy-1-methyl-propyl)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N⁴,N⁴-dimethyl-succinamide

Base Information

• Chemical Name: (S)-N¹-((S)-3-Benzylcarbamoyl-3,3-difluoro-2-hydroxy-1-methyl-propyl)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N⁴,N⁴-dimethyl-succinamide
• CAS No.: 198956-39-7
• Molecular Formula: C₃₀H₄₇F₂N₅O₆
• Molecular Weight: 611.73

Synonyms:(S)-N¹-((S)-3-Benzylcarbamoyl-3,3-difluoro-2-hydroxy-1-methyl-propyl)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N⁴,N⁴-dimethyl-succinamide

Chemical Property of (S)-N¹-((S)-3-Benzylcarbamoyl-3,3-difluoro-2-hydroxy-1-methyl-propyl)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N⁴,N⁴-dimethyl-succinamide

Chemical Property:

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Technology Process of (S)-N¹-((S)-3-Benzylcarbamoyl-3,3-difluoro-2-hydroxy-1-methyl-propyl)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N⁴,N⁴-dimethyl-succinamide

There total 7 articles about (S)-N¹-((S)-3-Benzylcarbamoyl-3,3-difluoro-2-hydroxy-1-methyl-propyl)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N⁴,N⁴-dimethyl-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R,S,4S)-(4-(N-tert-butoxycarbonyl)amino)-2,2-difluoro-3-hydroxypentanoic acid ethyl ester (200810-94-2) → (S)-N1-((S)-3-Benzylcarbamoyl-3,3-difluoro-2-hydroxy-1-methyl-propyl)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N4,N4-dimethyl-succinamide (198956-39-7)

Guidance literature:

Multi-step reaction with 7 steps

1: i-Pr₂NEt / ethanol / 18 h / Heating

2: HCl / dioxane / 0.5 h

3: BOP, i-Pr₂NEt / CH₂Cl₂ / 4 h

4: HCl / dioxane / 0.5 h

5: BOP, i-Pr₂NEt / CH₂Cl₂ / 4 h

6: HCl / dioxane / 1 h

7: BOP, i-Pr₂NEt / CH₂Cl₂ / 4 h

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane;

DOI:10.1021/jm970104t

Reference yield:

((S)-3-Benzylcarbamoyl-3,3-difluoro-2-hydroxy-1-methyl-propyl)-carbamic acid tert-butyl ester (198955-57-6) → (S)-N1-((S)-3-Benzylcarbamoyl-3,3-difluoro-2-hydroxy-1-methyl-propyl)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N4,N4-dimethyl-succinamide (198956-39-7)

Guidance literature:

Multi-step reaction with 6 steps

1: HCl / dioxane / 0.5 h

2: BOP, i-Pr₂NEt / CH₂Cl₂ / 4 h

3: HCl / dioxane / 0.5 h

4: BOP, i-Pr₂NEt / CH₂Cl₂ / 4 h

5: HCl / dioxane / 1 h

6: BOP, i-Pr₂NEt / CH₂Cl₂ / 4 h

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm970104t

Reference yield:

(S)-4-Amino-2,2-difluoro-3-hydroxy-pentanoic acid benzylamide; hydrochloride → (S)-N1-((S)-3-Benzylcarbamoyl-3,3-difluoro-2-hydroxy-1-methyl-propyl)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N4,N4-dimethyl-succinamide (198956-39-7)

Guidance literature:

Multi-step reaction with 5 steps

1: BOP, i-Pr₂NEt / CH₂Cl₂ / 4 h

2: HCl / dioxane / 0.5 h

3: BOP, i-Pr₂NEt / CH₂Cl₂ / 4 h

4: HCl / dioxane / 1 h

5: BOP, i-Pr₂NEt / CH₂Cl₂ / 4 h

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm970104t

upstream raw materials:

tert-Butylacetic acid

(3R,S,4S)-(4-(N-tert-butoxycarbonyl)amino)-2,2-difluoro-3-hydroxypentanoic acid ethyl ester

((S)-3-Benzylcarbamoyl-3,3-difluoro-2-hydroxy-1-methyl-propyl)-carbamic acid tert-butyl ester

[(S)-1-((S)-3-Benzylcarbamoyl-3,3-difluoro-2-hydroxy-1-methyl-propylcarbamoyl)-2-dimethylcarbamoyl-ethyl]-carbamic acid tert-butyl ester

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