4-fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)butyl]phenol

Base Information

Chemical Name:4-fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)butyl]phenol
CAS No.:1348286-12-3
Molecular Formula:C₁₉H₁₉F₄N₃O₂
Molecular Weight:397.372
Hs Code.:

Synonyms:4-fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)butyl]phenol

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Chemical Property of 4-fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)butyl]phenol

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Technology Process of 4-fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)butyl]phenol

There total 6 articles about 4-fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)butyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 875415-02-4
1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)pentan-2-ol

: 1348286-12-3
4-fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)butyl]phenol

Guidance literature:: With boron tribromide; In dichloromethane; at -15 - 0 ℃; for 60h; Inert atmosphere;
DOI:10.1021/jm4019178

Reference yield:

: 609806-82-8
1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-one

: 1348286-12-3
4-fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)butyl]phenol

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / 15 h / -78 - 20 °C / Inert atmosphere

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

3: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 17 h / 20 °C / Inert atmosphere

4: boron tribromide / dichloromethane / 60 h / -15 - 0 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; boron tribromide; triethylamine; In 1-methyl-pyrrolidin-2-one; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/jm4019178

Reference yield:

: 400-31-7
1,1,1-trifluoro-4-methyl-pent-3-en-2-one

: 1348286-12-3
4-fluoro-2-[4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)butyl]phenol

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide / diethyl ether; tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

2: diethyl ether / 15 h / -78 - 20 °C / Inert atmosphere

3: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

4: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 17 h / 20 °C / Inert atmosphere

5: boron tribromide / dichloromethane / 60 h / -15 - 0 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; boron tribromide; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/jm4019178