N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-N₁-{[4-(phenylmethyl)-2-morpholinyl]methyl}-L-leucinamide

Base Information

• Chemical Name: N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-N₁-{[4-(phenylmethyl)-2-morpholinyl]methyl}-L-leucinamide
• CAS No.: 911641-07-1
• Molecular Formula: C₂₃H₃₇N₃O₄
• Molecular Weight: 419.564

Synonyms:N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-N₁-{[4-(phenylmethyl)-2-morpholinyl]methyl}-L-leucinamide

Chemical Property of N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-N₁-{[4-(phenylmethyl)-2-morpholinyl]methyl}-L-leucinamide

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Technology Process of N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-N₁-{[4-(phenylmethyl)-2-morpholinyl]methyl}-L-leucinamide

There total 1 articles about N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-N₁-{[4-(phenylmethyl)-2-morpholinyl]methyl}-L-leucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + (4-benzylmorpholin-2-yl)methanamine (110859-47-7,140646-11-3) → N2-{[(1,1-dimethylethyl)oxy]carbonyl}-N1-{[4-(phenylmethyl)-2-morpholinyl]methyl}-L-leucinamide (911641-07-1)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 20 ℃; for 23h;

Reference yield:

N2-{[(1,1-dimethylethyl)oxy]carbonyl}-N1-{[4-(phenylmethyl)-2-morpholinyl]methyl}-L-leucinamide (911641-07-1) → N1-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-L-leucinamide (911641-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 27 h

2: triethylamine / dichloromethane / 120 h / 20 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 18 h

With hydrogenchloride; hydrogen; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

N2-{[(1,1-dimethylethyl)oxy]carbonyl}-N1-{[4-(phenylmethyl)-2-morpholinyl]methyl}-L-leucinamide (911641-07-1) → N1-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-N2-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide (911641-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 27 h

2: triethylamine / dichloromethane / 120 h / 20 °C

With hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;

upstream raw materials:

N-tert-butoxycarbonyl-L-leucine

(4-benzylmorpholin-2-yl)methanamine

Downstream raw materials:

N₁-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-L-leucinamide

N₁-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide

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