(2R,3S)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-4-methoxy-4-oxobutyl 4-methoxybenzoate

Base Information

Chemical Name:(2R,3S)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-4-methoxy-4-oxobutyl 4-methoxybenzoate
CAS No.:957146-88-2
Molecular Formula:C₁₈H₂₅NO₈
Molecular Weight:383.398
Hs Code.:

Synonyms:(2R,3S)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-4-methoxy-4-oxobutyl 4-methoxybenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-4-methoxy-4-oxobutyl 4-methoxybenzoate

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Technology Process of (2R,3S)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-4-methoxy-4-oxobutyl 4-methoxybenzoate

There total 5 articles about (2R,3S)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-4-methoxy-4-oxobutyl 4-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 4248-19-5
tert-butyl carbazate

: C₁₃H₁₄O₅

: 957146-88-2
(2R,3S)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-4-methoxy-4-oxobutyl 4-methoxybenzoate

Guidance literature:: With potassium osmate(VI) dihydrate; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane];
DOI:10.1002/chem.201604445

Reference yield: 89.0%

: 957146-89-3
(E)-4-methoxy-4-oxobut-2-en-1-yl 4-methoxybenzoate

: 4248-19-5
tert-butyl carbazate

: 957146-88-2
(2R,3S)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-4-methoxy-4-oxobutyl 4-methoxybenzoate

Guidance literature:: With potassium osmate(VI) dihydrate; 1,3-dichloro-5,5-dimethylhydantoin; 1,4-bis(9-O-dihydroquinidine)phthalazine; sodium hydroxide; In propan-1-ol; water; at 20 ℃;
DOI:10.1021/ol401110x

Reference yield:

: 6941-68-0
allyl 4-methoxybenzoate

: 957146-88-2
(2R,3S)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-4-methoxy-4-oxobutyl 4-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: osmium(VIII) oxide / diethyl ether / 0.17 h

1.2: 15.33 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 20 °C

3.1: sodium hydroxide; 1,3-dichloro-5,5-dimethylhydantoin; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium osmate(VI) dihydrate / water; propan-1-ol / 20 °C

With potassium osmate(VI) dihydrate; osmium(VIII) oxide; n-butyllithium; 1,3-dichloro-5,5-dimethylhydantoin; 1,4-bis(9-O-dihydroquinidine)phthalazine; sodium hydroxide; In tetrahydrofuran; propan-1-ol; diethyl ether; hexane; water;
DOI:10.1021/ol401110x