L-Proline, 4-hydroxy-5-(hydroxymethyl)-, (2-alpha-,4-alpha-,5-alpha-)- (9CI)

Base Information

Chemical Name:L-Proline, 4-hydroxy-5-(hydroxymethyl)-, (2-alpha-,4-alpha-,5-alpha-)- (9CI)
CAS No.:110658-38-3
Molecular Formula:C₆H₁₁NO₄
Molecular Weight:161.158
Hs Code.:
Mol file:110658-38-3.mol

Synonyms:L-Proline, 4-hydroxy-5-(hydroxymethyl)-, (2-alpha-,4-alpha-,5-alpha-)- (9CI)

Suppliers and Price of L-Proline, 4-hydroxy-5-(hydroxymethyl)-, (2-alpha-,4-alpha-,5-alpha-)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of L-Proline, 4-hydroxy-5-(hydroxymethyl)-, (2-alpha-,4-alpha-,5-alpha-)- (9CI)

Chemical Property:

Boiling Point:430.5±45.0 °C(Predicted)
PKA:2.04±0.60(Predicted)
PSA：89.79000
Density:1.431±0.06 g/cm3(Predicted)
LogP:-1.51650

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Proline, 4-hydroxy-5-(hydroxymethyl)-, (2-alpha-,4-alpha-,5-alpha-)- (9CI)

There total 13 articles about L-Proline, 4-hydroxy-5-(hydroxymethyl)-, (2-alpha-,4-alpha-,5-alpha-)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4S,5R)-4-Hydroxy-5-((1R,2S,3R)-1,2,3,4-tetrahydroxy-butyl)-pyrrolidine-2-carboxylic acid

: 110658-38-3,159247-18-4
(2S,4S,5S)-4-Hydroxy-5-hydroxymethyl-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: NaHCO₃ / H₂O / Ambient temperature

2: acetyl chloride / 3 h / Ambient temperature

3: LiOH / H₂O

4: NaIO₄

5: NaBH₄

6: H₂ / Pd/C

With lithium hydroxide; sodium tetrahydroborate; sodium periodate; hydrogen; sodium hydrogencarbonate; acetyl chloride; palladium on activated charcoal; In water;
DOI:10.1021/jo00053a051

Reference yield:

: (4S,5R)-4-Hydroxy-5-((1R,2S,3R)-1,2,3,4-tetrahydroxy-butyl)-pyrrolidine-2-carboxylic acid

: 95863-87-9,110658-38-3,159247-18-4
(2R,4S,5S)-4-Hydroxy-5-hydroxymethyl-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: NaHCO₃ / H₂O / Ambient temperature

2: acetyl chloride / 3 h / Ambient temperature

3: LiOH / H₂O

4: NaIO₄

5: NaBH₄

6: H₂ / Pd/C

With lithium hydroxide; sodium tetrahydroborate; sodium periodate; hydrogen; sodium hydrogencarbonate; acetyl chloride; palladium on activated charcoal; In water;
DOI:10.1021/jo00053a051

Reference yield:

: (4S,5R)-4-Hydroxy-5-((1R,2S,3R)-1,2,3,4-tetrahydroxy-butyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

: 110658-38-3,159247-18-4
(2S,4S,5S)-4-Hydroxy-5-hydroxymethyl-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: acetyl chloride / 3 h / Ambient temperature

2: LiOH / H₂O

3: NaIO₄

4: NaBH₄

5: H₂ / Pd/C

With lithium hydroxide; sodium tetrahydroborate; sodium periodate; hydrogen; acetyl chloride; palladium on activated charcoal; In water;
DOI:10.1021/jo00053a051